Iodipamide (free base) | CAS#606-17-7 (free base)

Iodipamide (free base)
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318062

CAS#: 606-17-7 (free base)

Description: Iodipamide (free base) is a molecule used as a contrast medium. When administered in vivo, iodipamide is removed from the liver and secreted into the biliary tract. Like other organic iodine compounds, this agent blocks x-rays and appears opaque on x-ray film; thereby it enhances the visibility of the bile ducts and gallbladder during cholangiography and cholecystography procedures.

Chemical Structure

Iodipamide (free base)

CAS# 606-17-7 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 318062
Name: Iodipamide (free base)
CAS#: 606-17-7 (free base)
Chemical Formula: C20H14I6N2O6
Exact Mass: 1,139.51
Molecular Weight: 1,139.762
Elemental Analysis: C, 21.08; H, 1.24; I, 66.81; N, 2.46; O, 8.42

Price and Availability

Size	Price	Availability
50mg	USD 150	Ready to Ship
100mg	USD 250	Ready to Ship
200mg	USD 450	Ready to Ship
500mg	USD 950	Ready to Ship
1g	USD 1650	Ready to Ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Iodipamide, Adipiodone, Biligrafin, Iodipamic acid, Bilignost, Bilignostum

IUPAC/Chemical Name: 3-[[6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoic acid

InChi Key: FFINMCNLQNTKLU-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14I6N2O6/c21-7-5-9(23)17(15(25)13(7)19(31)32)27-11(29)3-1-2-4-12(30)28-18-10(24)6-8(22)14(16(18)26)20(33)34/h5-6H,1-4H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34)

SMILES Code: O=C(O)C1=C(I)C=C(I)C(NC(CCCCC(NC2=C(I)C=C(I)C(C(O)=O)=C2I)=O)=O)=C1I

Appearance: Color: essentially colorless to light amber Form: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Certificate of Analysis:

View CoA: current batch, Lot# S7G12M05

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,139.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Huang H, Zeng JP, Long Y. [Hyponatremia induced by iodipamide: three cases report]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Jul;37(7):621. Chinese. PubMed PMID: 19961734.

2: Lee FT Jr, Sproat IA, Rappe AH, Violante MR, Bronson JP. Liver enhancement techniques in computed tomography. A comparison of intravenous bolus, computed tomographic portography, and iodipamide ethyl ester particle injections in a canine model. Invest Radiol. 1994 Jun;29 Suppl 2:S289-92. PubMed PMID: 7928259.

3: Yao SZ, Liu DZ, Nie LH. Potentiometric determination of iodipamide using an iodipamide ion-selective electrode. J Pharm Biomed Anal. 1990;8(4):373-7. PubMed PMID: 2100212.

4: Lauteala L, Kormano M, Violante MR. Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat. A morphological study. APMIS. 1988 Jul;96(7):660-6. PubMed PMID: 3408591.

5: Sands MS, Violante MR, Gadeholt G. Computed tomographic enhancement of liver and spleen in the dog with iodipamide ethyl ester particulate suspensions. Invest Radiol. 1987 May;22(5):408-16. PubMed PMID: 3597009.

6: Lauteala L, Kormano M, Violante MR. Effect of intravenously administered iodipamide ethyl ester particles on rat liver morphology. Invest Radiol. 1984 Mar-Apr;19(2):133-41. PubMed PMID: 6533104.

7: Durda PJ, Pagano RJ, Bauman N, Brockman JA. Effects of iodipamide on human C3 and factor B in vitro. J Allergy Clin Immunol. 1982 Nov;70(5):353-60. PubMed PMID: 6922882.

8: Arndt RD, Joyce PW, Gray RK, Haveson SB, Bos CJ. Iodipamide-enhanced computed tomography of the pancreas. Radiology. 1981 May;139(2):491-3. PubMed PMID: 7220894.

9: Koenig H, Grimm I. [Animal experiment studies on the distribution of 125I-iodipamide-meglumine (adipiodon) in the rat]. Z Gesamte Hyg. 1981;27(6):435-7. German. PubMed PMID: 7269697.

10: Burgener FA, Fischer HW. The effect of bilirubin on biliary iodipamide excretion in the dog. Invest Radiol. 1980 Mar-Apr;15(2):162-7. PubMed PMID: 7372427.

11: Witcombe JB. Renal tubular sludging of meglumine iodipamide (Biligrafin). Br J Radiol. 1978 Aug;51(608):579-83. PubMed PMID: 678750.

12: Burgener FA, Fischer HW, Denyon TD. Biliary excretion of iodipamide and iodoxamate in normal and common bile duct-obstructed dogs. Invest Radiol. 1978 May-Jun;13(3):255-63. PubMed PMID: 581381.

13: Thompson WM, Jones RS, Lang JH, Amberg JR. Effect of iopanoate on the biliary and urinary excretion of iodipamide. Invest Radiol. 1978 Jan-Feb;13(1):79-84. PubMed PMID: 632052.

14: Lin SK, Moss AA, Riegelman S. Iodipamide kinetics: capacity-limited biliary excretion with simultaneous pseudo-first-order renal excretion. J Pharm Sci. 1977 Dec;66(12):1670-4. PubMed PMID: 925927.

15: Loeb PM, Barnhart JL, Berk RN. Iotroxamide--a new intravenous cholangiographic agent. Comparison with iodipamide and the effect of bile salts. Radiology. 1977 Nov;125(2):323-9. PubMed PMID: 578579.

16: Tanimura H, Takenaka M, Setoyama M, Kamata T. [Drip infusion cholecysto-cholangiography with iodoxamate (BC-17) (III). Especially, compared with iodipamide (author's transl)]. Nihon Geka Hokan. 1977 May 1;46(3):313-25. Japanese. PubMed PMID: 578092.

17: Sutherland LR, Edwards LA, Medline A, Wilkinson RW, Connon JJ. Meglumine iodipamide (Cholografin) hepatotoxicity. Ann Intern Med. 1977 Apr;86(4):437-9. PubMed PMID: 848806.

18: Meier F, Siegismund G, Götz J. [Protracted anaphylactic shock after methyl-glucamine iodipamide (author's transl)]. Med Klin. 1976 Nov 19;71(47):2077-9. German. PubMed PMID: 1004356.

19: Evill CA, Benness GT. Cholangiographic excretion studies: a comparison of iodipamide and iodoxamate in the dog. Invest Radiol. 1976 SEP-OCT;11(5):459-63. PubMed PMID: 989759.

20: Burgener FA, Fischer HW. The effect of sodium taurocholate on biliary iodipamide excretion in the dog. Gastroenterology. 1976 Sep;71(3):475-8. PubMed PMID: 950099.

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Iodipamide (free base) featured