Y-29794 Tosylate
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MedKoo CAT#: 522636

CAS#: 143984-17-2 (tosylate); 129184-48-1 (free base)

Description: Y-29794 Tosylate is an orally active, potent and specific non-peptide prolyl endopeptidase (PPCE) inhibitor. Y-29794 selectively and competitively inhibited rat brain PPCE (Ki = 0.95 nM) in a reversible manner. Ex vivo study demonstrated that Y-29794 could penetrate into brain to exhibit dose-dependent and long-lasting inhibition. Furthermore, Y-29794 could potentiate the effect of TRH on the release of ACh in the rat hippocampus. Y-29794 prevents the progression of A beta-like deposition in the hippocampus of the SAM.


Price and Availability

Size
Price

2mg
USD 50
25mg
USD 250
200mg
USD 1250
2g
USD 6150
Size
Price

5mg
USD 90
50mg
USD 450
500mg
USD 2650
5g
Ask price
Size
Price

10mg
USD 150
100mg
USD 850
1g
USD 4650

Y29794 tosylate, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522636
Name: Y-29794 Tosylate
CAS#: 143984-17-2 (tosylate); 129184-48-1 (free base)
Chemical Formula: C30H42N2O4S3
Exact Mass:
Molecular Weight: 590.86
Elemental Analysis: C, 60.98; H, 7.17; N, 4.74; O, 10.83; S, 16.28


Synonym: Y 29794; Y-29794; Y29794; Y29794 tosylate; Y-29794 tosylate; Y 29794 tosylate.

IUPAC/Chemical Name: (2-((8-(dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate

SMILES Code: CC(C1=CC=C(C(C2=CC=CS2)=O)C(SCCCCCCCCN(C)C)=N1)C.CC3=CC=C(S(=O)(O)=O)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Y-29794 free base:
Chemical Formula: C23H34N2OS2
Exact Mass: 418.2113
Molecular Weight: 418.6580
Elemental Analysis: C, 65.99; H, 8.19; N, 6.69; O, 3.82; S, 15.32


References

1: Kato A, Fukunari A, Sakai Y, Nakajima T. Prevention of amyloid-like deposition
by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated
mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35. PubMed PMID: 9336340.

2: Nakajima T, Ono Y, Kato A, Maeda J, Ohe T. Y-29794--a non-peptide prolyl
endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992
Jul 20;141(2):156-60. PubMed PMID: 1436628.