Paclitaxel-MVCP
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MedKoo CAT#: 620102

CAS#: Unknown

Description: Paclitaxel-MVCP, also known as MC-Val-Cit-PAB-Paclitaxel, is a paclitaxel derivative with a MC-Val-Cit-PAB linker. Mc-Val-Cit-PAB is a cathepsin cleavable ADC peptide linker. Paclitaxel-MVCP can be used to conjugate with other molecules such as peptides, proteins, antibodies or enzymes, or polymers. Paclitaxel-MVCP is a useful agent to make Paclitaxel-conjugate for drug delivery, nanodrug research.


Price and Availability

Size
Price

2mg
USD 210
Size
Price

5mg
USD 420
Size
Price

10mg
USD 750

Paclitaxel-MVCP, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 10mg may be 2 months


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 620102
Name: Paclitaxel-MVCP
CAS#: Unknown
Chemical Formula: C76H89N7O22
Exact Mass: 1451.6061
Molecular Weight: 1452.575
Elemental Analysis: C, 62.84; H, 6.18; N, 6.75; O, 24.23


Synonym: Paclitaxel-MVCP; MC-Val-Cit-PAB-Paclitaxel, Paclitaxel conjugate.

IUPAC/Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-((((4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl)oxy)carbonyl)oxy)-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate

InChi Key: WKCOFIXYDRGLSO-WMBYQXBNSA-N

InChi Code: InChI=1S/C76H89N7O22/c1-42(2)59(81-55(87)29-19-12-20-37-83-56(88)34-35-57(83)89)68(93)80-51(28-21-36-78-71(77)96)67(92)79-50-32-30-46(31-33-50)40-99-72(97)103-62(60(47-22-13-9-14-23-47)82-66(91)48-24-15-10-16-25-48)70(95)102-52-39-76(98)65(104-69(94)49-26-17-11-18-27-49)63-74(8,53(86)38-54-75(63,41-100-54)105-45(5)85)64(90)61(101-44(4)84)58(43(52)3)73(76,6)7/h9-11,13-18,22-27,30-35,42,51-54,59-63,65,86,98H,12,19-21,28-29,36-41H2,1-8H3,(H,79,92)(H,80,93)(H,81,87)(H,82,91)(H3,77,78,96)/t51-,52-,53-,54+,59-,60-,61+,62+,63-,65-,74+,75-,76+/m0/s1

SMILES Code: O=C(C1=CC=CC=C1)O[C@H]([C@@]2(C[C@@H](C(C)=C([C@H]3OC(C)=O)C2(C)C)OC([C@H](OC(OCC(C=C4)=CC=C4NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)[C@H](C6=CC=CC=C6)NC(C7=CC=CC=C7)=O)=O)O)[C@]8([H])[C@@]9(CO[C@@]9(C[C@@H]([C@@](C3=O)8C)O)[H])OC(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Please also see similar products:
#610235: MC-Val-Cit-PAB (ADC peptide linker)
#610234: MC-Val-Cit-PAB-PNP (ADC peptide linker)


References

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2: Yin S, Huai J, Chen X, Yang Y, Zhang X, Gan Y, Wang G, Gu X, Li J. Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid. Acta Biomater. 2015 Oct 15;26:274-85. doi: 10.1016/j.actbio.2015.08.029. Epub 2015 Aug 20. PubMed PMID: 26300335.

3: He X, Lin M, Lu T, Qu Z, Xu F. Molecular analysis of interactions between a PAMAM dendrimer-paclitaxel conjugate and a biomembrane. Phys Chem Chem Phys. 2015 Nov 28;17(44):29507-17. doi: 10.1039/c5cp02242h. Epub 2015 Aug 10. PubMed PMID: 26256278.

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12: Wang Z, Hu X, Yue J, Jing X. Experimental study on biodegradable polymer-paclitaxel conjugate micelles for chemotherapy of C6 glioma. J Control Release. 2011 Nov 30;152 Suppl 1:e41-2. doi: 10.1016/j.jconrel.2011.08.110. PubMed PMID: 22195914.

13: Yang D, Van S, Liu J, Wang J, Jiang X, Wang Y, Yu L. Physicochemical properties and biocompatibility of a polymer-paclitaxel conjugate for cancer treatment. Int J Nanomedicine. 2011;6:2557-66. doi: 10.2147/IJN.S25044. Epub 2011 Oct 21. PubMed PMID: 22072890; PubMed Central PMCID: PMC3205149.

14: Galer CE, Sano D, Ghosh SC, Hah JH, Auzenne E, Hamir AN, Myers JN, Klostergaard J. Hyaluronic acid-paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism. Oral Oncol. 2011 Nov;47(11):1039-47. doi: 10.1016/j.oraloncology.2011.07.029. Epub 2011 Sep 7. PubMed PMID: 21903450.

15: Li S, Gray BP, McGuire MJ, Brown KC. Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin αvβ₆. Bioorg Med Chem. 2011 Sep 15;19(18):5480-9. doi: 10.1016/j.bmc.2011.07.046. Epub 2011 Aug 4. PubMed PMID: 21868241; PubMed Central PMCID: PMC3195361.

16: Wan Y, Zheng Y, Song X, Hu X, Liu S, Tong T, Jing X. Anti-tumor activity of biodegradable polymer-paclitaxel conjugate micelles on Lewis lung cancer mice models. J Biomater Sci Polym Ed. 2011;22(9):1131-46. doi: 10.1163/092050610X500570. PubMed PMID: 20594407.

17: Zhang SQ, Song YN, He XH, Zhong BH, Zhang ZQ. Liquid chromatography-tandem mass spectrometry for the determination of paclitaxel in rat plasma after intravenous administration of poly(L-glutamic acid)-alanine-paclitaxel conjugate. J Pharm Biomed Anal. 2010 Apr 6;51(5):1169-74. doi: 10.1016/j.jpba.2009.11.030. Epub 2009 Dec 4. PubMed PMID: 20036092.

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