Radiprodil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319896

CAS#: 496054-87-6

Description: Radiprodil, also known as RGH-896, is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatmen of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). Treatment with radiprodil did not show statistically significant or clinically meaningful reductions in mean daily pain scores, the primary endpoint, compared to placebo for any of the dosages studied. Based on preclinical pharmacology Radiprodil was a potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions.


Price and Availability

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Radiprodil is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international). Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319896
Name: Radiprodil
CAS#: 496054-87-6
Chemical Formula: C21H20FN3O4
Exact Mass: 397.1438
Molecular Weight: 397.4064
Elemental Analysis: C, 63.47; H, 5.07; F, 4.78; N, 10.57; O, 16.10


Synonym: RGH-896; RGH896; RGH 896; Radiprodil

IUPAC/Chemical Name: 2-(4-((4-Fluorophenyl)methyl)piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)acetamide

SMILES Code: O=C(NC1=CC=C2NC(OC2=C1)=O)C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Fernandes A, Wojcik T, Baireddy P, Pieschl R, Newton A, Tian Y, Hong Y,
Bristow L, Li YW. Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor
open channel blockers and GluN2B antagonists in rats and mice. Eur J Pharmacol.
2015 Nov 5;766:1-8. doi: 10.1016/j.ejphar.2015.08.044. Epub 2015 Aug 29. PubMed
PMID: 26325093.

2: Michel A, Downey P, Van Damme X, De Wolf C, Schwarting R, Scheller D.
Behavioural Assessment of the A2a/NR2B Combination in the Unilateral
6-OHDA-Lesioned Rat Model: A New Method to Examine the Therapeutic Potential of
Non-Dopaminergic Drugs. PLoS One. 2015 Aug 31;10(8):e0135949. doi:
10.1371/journal.pone.0135949. eCollection 2015. PubMed PMID: 26322641; PubMed
Central PMCID: PMC4555651.

3: Michel A, Downey P, Nicolas JM, Scheller D. Unprecedented therapeutic
potential with a combination of A2A/NR2B receptor antagonists as observed in the
6-OHDA lesioned rat model of Parkinson's disease. PLoS One. 2014 Dec
16;9(12):e114086. doi: 10.1371/journal.pone.0114086. eCollection 2014. PubMed
PMID: 25513815; PubMed Central PMCID: PMC4267740.