Gabapentin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317961

CAS#: 60142-96-3

Description: Gabapentin is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive. It is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain.


Price and Availability

Size
Price

1g
USD 150
10g
USD 450
100g
Ask price
Size
Price

2g
USD 280
20g
USD 550
Size
Price

5g
USD 350
50g
Ask price

Gabapentin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317961
Name: Gabapentin
CAS#: 60142-96-3
Chemical Formula: C9H17NO2
Exact Mass: 171.12593
Molecular Weight: 171.24
Elemental Analysis: C, 63.13; H, 10.01; N, 8.18; O, 18.69


Synonym: Gabapentin; Gabapentin; Neurontin; Gabapentine; 1-(Aminomethyl)cyclohexaneacetic acid; Aclonium; Convalis; gabapentin; Gabapentin Hexal; Gabapentin Stada; Gabapentin-ratiopharm; Neurontin; Novo-Gabapentin; PMS-Gabapentin;

IUPAC/Chemical Name: 2-[1-(aminomethyl)cyclohexyl]acetic acid

InChi Key: UGJMXCAKCUNAIE-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

SMILES Code: NCC1(CCCCC1)CC(=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bastiaens L, Galus J, Mazur C. Abuse of Gabapentin is Associated with Opioid
Addiction. Psychiatr Q. 2016 Feb 18. [Epub ahead of print] PubMed PMID: 26887855.

2: Miranda HF, Noriega V, Prieto J, Zanetta P, Castillo R, Aranda N, Sierralta F.
Antinociceptive Interaction of Tramadol with Gabapentin in Experimental
Mononeuropathic Pain. Basic Clin Pharmacol Toxicol. 2016 Feb 11. doi:
10.1111/bcpt.12567. [Epub ahead of print] PubMed PMID: 26867125.

3: Mersfelder TL, Nichols WH. Gabapentin: Abuse, Dependence, and Withdrawal. Ann
Pharmacother. 2016 Mar;50(3):229-33. doi: 10.1177/1060028015620800. Epub 2015 Dec
31. Review. PubMed PMID: 26721643.

4: Edwards L, DeMeo S, Hornik CD, Cotten CM, Smith PB, Pizoli C, Hauer JM,
Bidegain M. Gabapentin Use in the Neonatal Intensive Care Unit. J Pediatr. 2016
Feb;169:310-2. doi: 10.1016/j.jpeds.2015.10.013. Epub 2015 Nov 11. PubMed PMID:
26578075; PubMed Central PMCID: PMC4729593.

5: Hwang SH, Park IJ, Cho YJ, Jeong YM, Kang JM. The efficacy of
gabapentin/pregabalin in improving pain after tonsillectomy: A meta-analysis.
Laryngoscope. 2016 Feb;126(2):357-66. doi: 10.1002/lary.25636. Epub 2015 Sep 25.
PubMed PMID: 26404562.

6: Bugan I, Karagoz Z, Altun S, Djamgoz MB. Gabapentin, an Analgesic Used Against
Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an
In Vivo Rat Model. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):200-7. doi:
10.1111/bcpt.12484. Epub 2015 Oct 29. PubMed PMID: 26335695.

7: Besheer J, Frisbee S, Randall PA, Jaramillo AA, Masciello M. Gabapentin
potentiates sensitivity to the interoceptive effects of alcohol and increases
alcohol self-administration in rats. Neuropharmacology. 2016 Feb;101:216-24. doi:
10.1016/j.neuropharm.2015.09.027. Epub 2015 Sep 28. PubMed PMID: 26415538.

8: Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical
Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies
in Health; 2016 Jan 22. Available from
http://www.ncbi.nlm.nih.gov/books/NBK343848/
PubMed PMID: 26889527.

9: Calkins AM, Gudin J, Gidal B, Jaros MJ, Kim R, Shang G. Impact of Data
Imputation Methodology on Pain Assessment over 24 Hours in a Randomized,
Placebo-Controlled Study of Gabapentin Enacarbil in Patients with Neuropathic
Pain Associated with Postherpetic Neuralgia. Pain Med. 2016 Jan 6. pii: pnv072.
[Epub ahead of print] PubMed PMID: 26814307.

10: Abe K, Chiba Y, Katsuse O, Hirayasu Y. A Case of Parkinson Disease With Both
Visual Hallucination and Pain Improved by Gabapentin. Clin Neuropharmacol. 2016
Jan-Feb;39(1):55-6. doi: 10.1097/WNF.0000000000000122. PubMed PMID: 26757314.

11: Yang W, McNutt TR, Dudley SA, Kumar R, Starmer HM, Gourin CG, Moore JA, Evans
K, Allen M, Agrawal N, Richmon JD, Chung CH, Quon H. Predictive Factors for
Prophylactic Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement and Use in
Head and Neck Patients Following Intensity-Modulated Radiation Therapy (IMRT)
Treatment: Concordance, Discrepancies, and the Role of Gabapentin. Dysphagia.
2016 Jan 11. [Epub ahead of print] PubMed PMID: 26753929.

12: Reda HM, Zaitone SA, Moustafa YM. Effect of levetiracetam versus gabapentin
on peripheral neuropathy and sciatic degeneration in streptozotocin-diabetic
mice: Influence on spinal microglia and astrocytes. Eur J Pharmacol. 2016 Jan
15;771:162-72. doi: 10.1016/j.ejphar.2015.12.035. Epub 2015 Dec 19. PubMed PMID:
26712375.

13: Papathanasiou T, Juul RV, Heegaard AM, Kreilgaard M, Lund TM.
Co-administration of morphine and gabapentin leads to dose dependent synergistic
effects in a rat model of postoperative pain. Eur J Pharm Sci. 2016 Jan
20;82:97-105. doi: 10.1016/j.ejps.2015.11.015. Epub 2015 Nov 21. PubMed PMID:
26610393.

14: Liow NY, Gimeno H, Lumsden DE, Marianczak J, Kaminska M, Tomlin S, Lin JP.
Gabapentin can significantly improve dystonia severity and quality of life in
children. Eur J Paediatr Neurol. 2016 Jan;20(1):100-7. doi:
10.1016/j.ejpn.2015.09.007. Epub 2015 Sep 28. PubMed PMID: 26455274.

15: Bellows BK, Nelson RE, Oderda GM, LaFleur J. Long-term cost-effectiveness of
initiating treatment for painful diabetic neuropathy with pregabalin, duloxetine,
gabapentin, or desipramine. Pain. 2016 Jan;157(1):203-13. doi:
10.1097/j.pain.0000000000000350. PubMed PMID: 26397932.

16: Mimenza Alvarado A, Aguilar Navarro S. Clinical Trial Assessing the Efficacy
of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful
Diabetic Neuropathy. J Diabetes Res. 2016;2016:4078695. doi:
10.1155/2016/4078695. Epub 2016 Jan 17. PubMed PMID: 26885528.

17: Lee EG, Lee HJ, Hyun DJ, Min K, Kim DH, Yoon MS. Efficacy of low dose
gabapentin in acute herpes zoster for preventing postherpetic neuralgia: a
prospective controlled study. Dermatol Ther. 2016 Jan 22. doi: 10.1111/dth.12331.
[Epub ahead of print] PubMed PMID: 26799145.

18: Larsen MS, Keizer R, Munro G, Mørk A, Holm R, Savic R, Kreilgaard M.
Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced
Inflammatory Hyperalgesia Rat Model. Pharm Res. 2016 Jan 15. [Epub ahead of
print] PubMed PMID: 26780452.

19: Ostadhadi S, Kordjazy N, Haj-Mirzaian A, Ameli S, Akhlaghipour G, Dehpour A.
Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in
mouse forced swimming test. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan 12.
[Epub ahead of print] PubMed PMID: 26753696.

20: Marashi SM, Saeedinia SM, Sadeghi M, Movafegh A, Marashi S. Attenuation of
Hemodynamic Responses to Intubation by Gabapentin in Coronary Artery Bypass
Surgery: a Randomized Clinical Trial. Acta Med Iran. 2015 Dec;53(12):733-7.
PubMed PMID: 26749228.