Bentamapimod
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319883

CAS#: 848344-36-5

Description: Bentamapimod, also known as AS602801 and PGL5001, is a JNK Inhibitor. AS602801 induces regression of endometriotic lesions in animal models. AS602801 interrupts immune pathways. Bentamapimod induced regression of endometriotic lesions in endometriosis rodent animal models without suppressing ER action. Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites.


Price and Availability

Size
Price

10mg
Not available
100mg
USD 1350
1g
USD 3650
Size
Price

25mg
Not available
200mg
USD 1950
2g
USD 5650
Size
Price

50mg
Not available
500mg
USD 2650
5g
Ask price

Bentamapimod, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 319883
Name: Bentamapimod
CAS#: 848344-36-5
Chemical Formula: C25H23N5O2S
Exact Mass: 457.1572
Molecular Weight: 457.552
Elemental Analysis: C, 65.63; H, 5.07; N, 15.31; O, 6.99; S, 7.01


Synonym: AS602801; AS-602801; AS 602801; PGL5001; PGL-5001; PGL 5001; Bentamapimod

IUPAC/Chemical Name: 2-(1,3-benzothiazol-2-yl)-2-[2-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)pyrimidin-4-yl]acetonitrile

InChi Key: XCPPIJCBCWUBNT-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2

SMILES Code: N#CC(C1=NC2=CC=CC=C2S1)C3=NC(OCC4=CC=C(CN5CCOCC5)C=C4)=NC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hussein M, Chai DC, Kyama CM, Mwenda JM, Palmer SS, Gotteland JP, D'Hooghe TM.
c-Jun NH(2)-terminal kinase inhibitor bentamapimod reduces induced endometriosis
in baboons: an assessor-blind placebo-controlled randomized study. Fertil Steril.
2015 Dec 2. pii: S0015-0282(15)02106-8. doi: 10.1016/j.fertnstert.2015.11.022.
[Epub ahead of print] PubMed PMID: 26654972.

2: Palmer SS, Altan M, Denis D, Tos EG, Gotteland JP, Osteen KG, Bruner-Tran KL,
Nataraja SG. Bentamapimod (JNK Inhibitor AS602801) Induces Regression of
Endometriotic Lesions in Animal Models. Reprod Sci. 2016 Jan;23(1):11-23. doi:
10.1177/1933719115600553. Epub 2015 Sep 2. PubMed PMID: 26335175.