Lagociclovir

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319833

CAS#: 92562-88-4

Description: Lagociclovir, also known as MIV-210, is a high oral bioavailability antiviral agent with potent activity against hepatitis B virus (HBV). MIV-210 may be a highly valuable candidate for further testing as an agent against chronic hepatitis B.


Chemical Structure

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Lagociclovir
CAS# 92562-88-4

Theoretical Analysis

MedKoo Cat#: 319833
Name: Lagociclovir
CAS#: 92562-88-4
Chemical Formula: C10H12FN5O3
Exact Mass: 269.09
Molecular Weight: 269.236
Elemental Analysis: C, 44.61; H, 4.49; F, 7.06; N, 26.01; O, 17.83

Price and Availability

Size Price Availability Quantity
10mg USD -2
25mg USD -2
50mg USD -2
100mg USD -2
200mg USD -2
500mg USD -2
20g USD -1
1g USD -1
2g USD -1
5g USD -1
10g USD -1
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Synonym: MIV-210; MIV 210; MIV210; 3'-FddG; Fddguo; Lagociclovir.

IUPAC/Chemical Name: 2-amino-9-((2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one

InChi Key: RTJUXLYUUDBAJN-KVQBGUIXSA-N

InChi Code: InChI=1S/C10H12FN5O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1

SMILES Code: OC[C@@H]1[C@@H](F)C[C@H](N2C=NC3=C2N=C(N)NC3=O)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 269.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Michalak TI, Zhang H, Churchill ND, Larsson T, Johansson NG, Oberg B. Profound
antiviral effect of oral administration of MIV-210 on chronic hepadnaviral
infection in a woodchuck model of hepatitis B. Antimicrob Agents Chemother. 2009
Sep;53(9):3803-14. doi: 10.1128/AAC.00263-09. Epub 2009 Jun 29. PubMed PMID:
19564357; PubMed Central PMCID: PMC2737870.


2: De Clercq E. Emerging anti-HIV drugs. Expert Opin Emerg Drugs. 2005
May;10(2):241-73. Review. PubMed PMID: 15934866.