Elpetrigine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319824

CAS#: 212778-82-0

Description: Elpetrigine, also known as GW 273293 and JZP-4, is a potent calcium and sodium channel blocker, which is currently being evaluated in patients as an anticonvulsant and mood stabilizer. JZP-4 could have anxiolytic effects in addition to the anticonvulsant, antidepressant and antimania effects reported earlier.


Chemical Structure

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Elpetrigine
CAS# 212778-82-0

Theoretical Analysis

MedKoo Cat#: 319824
Name: Elpetrigine
CAS#: 212778-82-0
Chemical Formula: C10H7Cl3N4
Exact Mass: 287.97
Molecular Weight: 289.544
Elemental Analysis: C, 41.48; H, 2.44; Cl, 36.73; N, 19.35

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GW273293; GW-273293; GW 273293; JZP-4; JZP 4; JZP4; Elpetrigine.

IUPAC/Chemical Name: 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine

InChi Key: NNXUYJFHOVCRSM-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H7Cl3N4/c11-4-1-5(8(13)6(12)2-4)9-10(15)17-7(14)3-16-9/h1-3H,(H4,14,15,17)

SMILES Code: NC1=NC(N)=CN=C1C2=CC(Cl)=CC(Cl)=C2Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 289.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin
Pharmacol. 2009 Mar;31(2):107-46. PubMed PMID: 19455266.


2: Foreman MM, Hanania T, Eller M. Anxiolytic effects of lamotrigine and JZP-4 in
the elevated plus maze and in the four plate conflict test. Eur J Pharmacol. 2009
Jan 14;602(2-3):316-20. doi: 10.1016/j.ejphar.2008.11.013. Epub 2008 Nov 17.
PubMed PMID: 19038245.


3: Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress
report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT
IX). Epilepsy Res. 2009 Jan;83(1):1-43. doi: 10.1016/j.eplepsyres.2008.09.005.
Epub 2008 Nov 12. PubMed PMID: 19008076.


4: Foreman MM, Hanania T, Stratton SC, Wilcox KS, White HS, Stables JP, Eller M.
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for
anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav.
2008 Jun;89(4):523-34. doi: 10.1016/j.pbb.2008.02.007. Epub 2008 Feb 11. PubMed
PMID: 18377968.


5: Landmark CJ, Johannessen SI. Modifications of antiepileptic drugs for improved
tolerability and efficacy. Perspect Medicin Chem. 2008 Feb 14;2:21-39. PubMed
PMID: 19787095; PubMed Central PMCID: PMC2746576.


6: Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Perucca E, Tomson T.
Progress report on new antiepileptic drugs: a summary of the Eigth Eilat
Conference (EILAT VIII). Epilepsy Res. 2007 Jan;73(1):1-52. Epub 2006 Dec 8.
PubMed PMID: 17158031.