Budiodarone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319821

CAS#: 335148-45-3

Description: Budiodarone, also known as ATI-2042, is an antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials. Budiodarone holds much promise as an antiarrhythmic drug to prevent fibrillation.


Price and Availability

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10mg
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100mg
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1g
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10g
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25mg
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200mg
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2g
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20g
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50mg
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500mg
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5g
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50g
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Budiodarone, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319821
Name: Budiodarone
CAS#: 335148-45-3
Chemical Formula: C27H31I2NO5
Exact Mass: 703.0292
Molecular Weight: 703.3559
Elemental Analysis: C, 46.11; H, 4.44; I, 36.09; N, 1.99; O, 11.37


Synonym: ATI-2042; ATI2042; ATI 2042; Budiodarone

IUPAC/Chemical Name: (S)-sec-butyl 2-(3-(4-(2-(diethylamino)ethoxy)-3,5-diiodobenzoyl)benzofuran-2-yl)acetate

InChi Key: ZXOSVKYCXLTVGS-KRWDZBQOSA-N

InChi Code: InChI=1S/C27H31I2NO5/c1-5-17(4)34-24(31)16-23-25(19-10-8-9-11-22(19)35-23)26(32)18-14-20(28)27(21(29)15-18)33-13-12-30(6-2)7-3/h8-11,14-15,17H,5-7,12-13,16H2,1-4H3/t17-/m0/s1

SMILES Code: O=C(O[C@@H](C)CC)CC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=CC=CC=C3O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS# CAS#
335148-45-3 (Budiodarone)
478941-93-4 (Budiodarone tartrate)


References

1: Buchwald P, Bodor N. Recent advances in the design and development of soft
drugs. Pharmazie. 2014 Jun;69(6):403-13. Review. PubMed PMID: 24974571.

2: Ezekowitz MD, Nagarakanti R, Lubinski A, Bandman O, Canafax D, Ellis DJ,
Milner PG, Ziola M, Thibault B, Hohnloser SH; PASCAL Investigators. A randomized
trial of budiodarone in paroxysmal atrial fibrillation. J Interv Card
Electrophysiol. 2012 Jun;34(1):1-9. doi: 10.1007/s10840-011-9636-3. Epub 2011 Dec
29. PubMed PMID: 22205496.

3: Mason PK, DiMarco JP. New pharmacological agents for arrhythmias. Circ
Arrhythm Electrophysiol. 2009 Oct;2(5):588-97. doi: 10.1161/CIRCEP.109.884429.
Review. PubMed PMID: 19843928.

4: Arya A, Silberbauer J, Teichman SL, Milner P, Sulke N, Camm AJ. A preliminary
assessment of the effects of ATI-2042 in subjects with paroxysmal atrial
fibrillation using implanted pacemaker methodology. Europace. 2009
Apr;11(4):458-64. doi: 10.1093/europace/eun384. Epub 2009 Jan 26. PubMed PMID:
19174378; PubMed Central PMCID: PMC2659603.