Odelepran

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319732

CAS#: 676501-25-0

Description: Odelepran, also known as LY2196044, is a opioid receptor antagonist under development for the treatment of alcohol dependence. Endogenous opioid-mediated reward pathways may play a role in the development and maintenance of alcohol dependence.


Price and Availability

Size
Price

10mg
Not available
100mg
Not available
1g
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Size
Price

25mg
Not available
200mg
Not available
2g
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Size
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50mg
Not available
500mg
Not available
5g
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Odelepran is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319732
Name: Odelepran
CAS#: 676501-25-0
Chemical Formula: C20H24FN3O3
Exact Mass: 373.1802
Molecular Weight: 373.4284
Elemental Analysis: C, 64.33; H, 6.48; F, 5.09; N, 11.25; O, 12.85


Synonym: LY2196044; LY 2196044; LY-2196044; Odelepran

IUPAC/Chemical Name: 6-(2-fluoro-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)nicotinamide

InChi Key: QWNDOCKIKKQJNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24FN3O3/c21-17-11-15(12-23-8-5-14-6-9-26-10-7-14)1-3-18(17)27-19-4-2-16(13-24-19)20(22)25/h1-4,11,13-14,23H,5-10,12H2,(H2,22,25)

SMILES Code: O=C(C1=CC=C(OC2=CC=C(CNCCC3CCOCC3)C=C2F)N=C1)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wong CJ, Witcher J, Mallinckrodt C, Dean RA, Anton RF, Chen Y, Fijal BA,
Ouyang H, Dharia S, Sundseth SS, Schuh KJ, Kinon BJ. A phase 2,
placebo-controlled study of the opioid receptor antagonist LY2196044 for the
treatment of alcohol dependence. Alcohol Clin Exp Res. 2014 Feb;38(2):511-20.
doi: 10.1111/acer.12257. Epub 2013 Sep 6. PubMed PMID: 24010675.

2: Ding X, He M, Kulkarni R, Patel N, Zhang X. Investigation of clinical
pharmacokinetic variability of an opioid antagonist through physiologically based
absorption modeling. J Pharm Sci. 2013 Aug;102(8):2859-74. doi:
10.1002/jps.23629. Epub 2013 Jun 11. PubMed PMID: 23761048.

3: Hillemacher T, Heberlein A, Muschler MA, Bleich S, Frieling H. Opioid
modulators for alcohol dependence. Expert Opin Investig Drugs. 2011
Aug;20(8):1073-86. doi: 10.1517/13543784.2011.592139. Epub 2011 Jun 9. Review.
PubMed PMID: 21651459.