Zamicastat

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319706

CAS#: 1080028-80-3 (free base)

Description: Zamicastat is a potent and selective dopamine β-mono-oxygenase inhibitor. Zamicastat Prevents the Deterioration of Cardiometabolic and Inflammatory Biomarkers in a Genetic Model of Salt-sensitive Hypertension. Chronic high salt intake deteriorates several cardiometabolic and inflammatory biomarkers in Dahl/SS rats, which can be prevented by dopamine β-hydroxylase inhibition with zamicastat.


Price and Availability

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1g
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10g
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2g
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20g
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Size
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5g
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Zamicastat, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 2 months after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319706
Name: Zamicastat
CAS#: 1080028-80-3 (free base)
Chemical Formula: C21H21F2N3OS
Exact Mass: 401.1373
Molecular Weight: 401.4758
Elemental Analysis: C, 62.83; H, 5.27; F, 9.46; N, 10.47; O, 3.99; S, 7.99


Related CAS #: 1080028-80-3 (free base)   1383828-47-4 (HCl)    

Synonym: Zamicastat

IUPAC/Chemical Name: (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione

InChi Key: ZSSLCFLHEFXANG-GOSISDBHSA-N

InChi Code: InChI=1S/C21H21F2N3OS/c22-16-8-15-9-18(13-27-20(15)19(23)10-16)26-17(12-25-21(26)28)6-7-24-11-14-4-2-1-3-5-14/h1-5,8,10,12,18,24H,6-7,9,11,13H2,(H,25,28)/t18-/m1/s1

SMILES Code: S=C(N1[C@@H]2CC3=CC(F)=CC(F)=C3OC2)NC=C1CCNCC4=CC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
1080028-80-3 ( Zamicastat free base)
1383828-47-4 ( Zamicastat HCl salt).