Funapide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319646

CAS#: 1259933-16-8

Description: Funapide, aslo known as TV-45070 and XEN402, is a novel analgesic agent which may be useful for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain. Funapide acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker.


Chemical Structure

img
Funapide
CAS# 1259933-16-8

Theoretical Analysis

MedKoo Cat#: 319646
Name: Funapide
CAS#: 1259933-16-8
Chemical Formula: C22H14F3NO5
Exact Mass: 429.08
Molecular Weight: 429.350
Elemental Analysis: C, 61.54; H, 3.29; F, 13.27; N, 3.26; O, 18.63

Price and Availability

Size Price Availability Quantity
1g USD -1
2g USD -1
5g USD -1
10g USD -1
Bulk inquiry

Synonym: TV-45070; TV 45070; TV45070; XEN402; XEN-402; XEN 402; Funapide.

IUPAC/Chemical Name: (3'S)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-2H,6H-spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

InChi Key: NEBUOXBYNAHKFV-NRFANRHFSA-N

InChi Code: InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1

SMILES Code: O=C([C@]12COC3=C1C=C(OCO4)C4=C3)N(CC5=CC=C(C(F)(F)F)O5)C6=C2C=CC=C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA. Recent progress
in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug
15;24(16):3690-9. doi: 10.1016/j.bmcl.2014.06.038. Epub 2014 Jun 21. Review.
PubMed PMID: 25060923.


2: Goldberg YP, Pimstone SN, Namdari R, Price N, Cohen C, Sherrington RP, Hayden
MR. Human Mendelian pain disorders: a key to discovery and validation of novel
analgesics. Clin Genet. 2012 Oct;82(4):367-73. doi:
10.1111/j.1399-0004.2012.01942.x. Epub 2012 Aug 13. Review. PubMed PMID:
22845492.


3: Goldberg YP, Price N, Namdari R, Cohen CJ, Lamers MH, Winters C, Price J,
Young CE, Verschoof H, Sherrington R, Pimstone SN, Hayden MR. Treatment of
Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel
blocker. Pain. 2012 Jan;153(1):80-5. doi: 10.1016/j.pain.2011.09.008. Epub 2011
Oct 28. PubMed PMID: 22035805.


4: Mai G, del Rio ML, Tian J, Ramirez P, Buhler L, Rodriguez-Barbosa JI. Blockade
of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in
a rat to mouse concordant islet xenotransplantation model. Xenotransplantation.
2007 May;14(3):243-8. PubMed PMID: 17489865.