Dapaconazole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319643

CAS#: 1269726-67-1

Description: Dapaconazole is an antifungal drug candidate. Phase II trials showed that Dapaconazole tosylate is non-inferior to ketoconazole when used at a dose of 20 mg/day for 28 consecutive days for the treatment of PV. Dapaconazole also demonstrated a good safety profile.


Price and Availability

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Price

1g
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10g
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Size
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2g
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20g
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Size
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5g
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Dapaconazole is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319643
Name: Dapaconazole
CAS#: 1269726-67-1
Chemical Formula: C19H15Cl2F3N2O
Exact Mass: 414.0514
Molecular Weight: 415.2372
Elemental Analysis: C, 54.96; H, 3.64; Cl, 17.07; F, 13.73; N, 6.75; O, 3.85


Synonym: Dapaconazole

IUPAC/Chemical Name: 1-(2-(2,4-dichlorophenyl)-2-((4-(trifluoromethyl)benzyl)oxy)ethyl)-1H-imidazole

InChi Key: FUAHXHWSMYFWGE-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H15Cl2F3N2O/c20-15-5-6-16(17(21)9-15)18(10-26-8-7-25-12-26)27-11-13-1-3-14(4-2-13)19(22,23)24/h1-9,12,18H,10-11H2

SMILES Code: FC(C1=CC=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gobbato AA, Babadópulos T, Gobbato CA, Ilha Jde O, Gagliano-Jucá T, De Nucci
G. A randomized double-blind, non-inferiority Phase II trial, comparing
dapaconazole tosylate 2% cream with ketoconazole 2% cream in the treatment of
Pityriasis versicolor. Expert Opin Investig Drugs. 2015 Nov;24(11):1399-407. doi:
10.1517/13543784.2015.1083009. Epub 2015 Sep 30. PubMed PMID: 26419668.

2: de Moraes FC, Bittencourt SF, Perissutti E, Frencentese F, Arruda AM, Chen LS,
Babadópulos T, De Nucci G. Quantification of dapaconazole in human plasma using
high-performance liquid chromatography coupled to tandem mass spectrometry:
application to a phase I study. J Chromatogr B Analyt Technol Biomed Life Sci.
2014 May 1;958:102-7. doi: 10.1016/j.jchromb.2014.01.053. Epub 2014 Mar 12.
PubMed PMID: 24705538.