Fludrocortisone
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MedKoo CAT#: 317881

CAS#: 127-31-1 (free)

Description: Fludrocortisone is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. Therapeutically, it is used for its mineralocorticoid activity and not for its glucocorticoid activity. Fludrocortisone has been used in the treatment of cerebral salt wasting syndrome. However, it is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. Due to its effects on increasing Na+ levels, and therefore blood volume, fludrocortisone is the first line of treatment for orthostatic intolerance and postural orthostatic tachycardia syndrome (POTS). It can be used to treat low blood pressure. Fludrocortisone is also used as a confirmation test for diagnosing Conn's syndrome (aldosterone producing-adrenal adenoma).

Chemical Structure

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Fludrocortisone
CAS# 127-31-1 (free)
Instruction

Theoretical Analysis

MedKoo Cat#: 317881
Name: Fludrocortisone
CAS#: 127-31-1 (free)
Chemical Formula: C21H29FO5
Exact Mass: 380.20
Molecular Weight: 380.450
Elemental Analysis: C, 66.30; H, 7.68; F, 4.99; O, 21.03

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 Weeks
10mg USD 750 2 Weeks
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Related CAS #: 127-31-1 (free)   514-36-3 (acetate)   339-01-5 (hemisuccinate)    

Synonym: Fludrocortisone, Astonin, 9α-fluorocortisol, 9α-fluorohydrocortisone, Florinef, Fludrocortisone acetate

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

InChi Key: AAXVEMMRQDVLJB-BULBTXNYSA-N

InChi Code: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

SMILES Code: C[C@]12CCC(C=C1CC[C@@H]3[C@]2(F)[C@@H](O)C[C@@]4(C)[C@H]3CC[C@]4(O)C(CO)=O)=O

Appearance: White to light yellow crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 380.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fleischer J, Wingenfeld K, Kuehl LK, Hinkelmann K, Roepke S, Otte C. Does fludrocortisone influence autobiographical memory retrieval? A study in patients with major depression, patients with borderline personality disorder and healthy controls. Stress. 2015 Nov;18(6):718-22. doi: 10.3109/10253890.2015.1087504. Epub 2015 Oct 12. PubMed PMID: 26457343.

2: Koutinas CK, Soubasis NC, Djajadiningrat-Laanen SC, Kolia E, Theodorou K. Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat. J Am Anim Hosp Assoc. 2015 Sep-Oct;51(5):338-41. doi: 10.5326/JAAHA-MS-6201. PubMed PMID: 26355586.

3: Johnson RF, Beltz TG, Johnson AK, Thunhorst RL. Effects of fludrocortisone on water and sodium intake of C57BL/6 mice. Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R247-54. doi: 10.1152/ajpregu.00033.2015. Epub 2015 May 27. PubMed PMID: 26017491; PubMed Central PMCID: PMC4525329.

4: Schultebraucks K, Wingenfeld K, Otte C, Quinkler M. The Role of Fludrocortisone in Cognition and Mood in Patients with Primary Adrenal Insufficiency (Addison's Disease). Neuroendocrinology. 2015 Jul 24. [Epub ahead of print] PubMed PMID: 26227663.

5: Banda J, Lakshmanan R, Vvs SP, Gudla SP, Prudhivi R. A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application. Biomed Chromatogr. 2015 Aug;29(8):1213-9. doi: 10.1002/bmc.3410. Epub 2015 Jan 22. PubMed PMID: 25611194.

6: Matsuda M, Behrend EN, Kemppainen R, Refsal K, Johnson A, Lee H. Serum aldosterone and cortisol concentrations before and after suppression with fludrocortisone in cats: a pilot study. J Vet Diagn Invest. 2015 May;27(3):361-8. doi: 10.1177/1040638715583530. Epub 2015 Apr 21. PubMed PMID: 25901003.

7: Wingenfeld K, Kuehl LK, Janke K, Hinkelmann K, Eckert FC, Roepke S, Otte C. Effects of mineralocorticoid receptor stimulation via fludrocortisone on memory in women with borderline personality disorder. Neurobiol Learn Mem. 2015 Apr;120:94-100. doi: 10.1016/j.nlm.2015.02.013. Epub 2015 Feb 28. PubMed PMID: 25732250.

8: Jaal J, Jõgi T, Altraja A. Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone. Case Rep Oncol Med. 2015;2015:286029. doi: 10.1155/2015/286029. Epub 2015 Jul 9. PubMed PMID: 26240768; PubMed Central PMCID: PMC4512576.

9: Bonfig W, Schwarz HP. Blood pressure, fludrocortisone dose and plasma renin activity in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency followed from birth to 4 years of age. Clin Endocrinol (Oxf). 2014 Dec;81(6):871-5. doi: 10.1111/cen.12498. Epub 2014 Jun 17. PubMed PMID: 24818525.

10: Rizk M, El Khatib M, Yamout B, Hujeily E, Ayoub S, Ayoub C, Skaf G. Spontaneous intracranial hypotension syndrome treated with fludrocortisone. A A Case Rep. 2015 Jan 1;4(1):8-11. doi: 10.1213/XAA.0000000000000105. PubMed PMID: 25612272.

11: Whyte IM, Prior FH, Emslie IK, Davies PE, Cosgrove J. Posterior subcapsular cataract in association with fludrocortisone acetate therapy. Clin Experiment Ophthalmol. 2014 Nov;42(8):799-800. doi: 10.1111/ceo.12326. Epub 2014 May 5. PubMed PMID: 24641708.

12: Bacchetta J, Basmaison O, Leclerc AL, Bertholet-Thomas A, Cochat P, Ranchin B. Fludrocortisone as a new tool for managing tubulopathy after pediatric renal transplantation: a series of cases. Pediatr Nephrol. 2014 Oct;29(10):2061-4. doi: 10.1007/s00467-014-2842-3. Epub 2014 Jun 9. PubMed PMID: 24908322.

13: Asehnoune K, Seguin P, Allary J, Feuillet F, Lasocki S, Cook F, Floch H, Chabanne R, Geeraerts T, Roger C, Perrigault PF, Hanouz JL, Lukaszewicz AC, Biais M, Boucheix P, Dahyot-Fizelier C, Capdevila X, Mahe PJ, Le Maguet P, Paugam-Burtz C, Gergaud S, Plaud B, Constantin JM, Malledant Y, Flet L, Sebille V, Roquilly A; Corti-TC Study Group. Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial. Lancet Respir Med. 2014 Sep;2(9):706-16. doi: 10.1016/S2213-2600(14)70144-4. Epub 2014 Jul 24. Erratum in: Lancet Respir Med. 2014 Sep;2(9):e15. PubMed PMID: 25066331.

14: Baumstark ME, Nussberger J, Boretti FS, Baumstark MW, Riond B, Reusch CE, Sieber-Ruckstuhl NS. Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone. J Vet Intern Med. 2014 Sep-Oct;28(5):1471-8. doi: 10.1111/jvim.12426. PubMed PMID: 25274440.

15: Fortunato JE, Wagoner AL, Harbinson RL, D'Agostino RB Jr, Shaltout HA, Diz DI. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):39-43. doi: 10.1097/MPG.0000000000000305. PubMed PMID: 25222805.

16: Laviolle B, Nesseler N, Massart C, Bellissant E. Fludrocortisone and hydrocortisone, alone or in combination, on in vivo hemodynamics and in vitro vascular reactivity in normal and endotoxemic rats: a randomized factorial design study. J Cardiovasc Pharmacol. 2014 Jun;63(6):488-96. doi: 10.1097/FJC.0000000000000072. PubMed PMID: 24390176.

17: Sivakumar V, Sriramnaveen P, Krishna C, Manjusha Y, Reddy YS, Sridhar N, Subramanian S. Role of fludrocortisone in the management of tacrolimus-induced hyperkalemia in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014 Jan;25(1):149-51. PubMed PMID: 24434399.

18: Vaishnav M, Patel V, Varghese SP, McCagh JC, Koola MM. Fludrocortisone in posttraumatic stress disorder: effective for symptoms and prazosin-induced hypotension. Prim Care Companion CNS Disord. 2014 Dec 4;16(6). doi: 10.4088/PCC.14l01676. eCollection 2014. PubMed PMID: 25834757; PubMed Central PMCID: PMC4374816.

19: Djajadiningrat-Laanen SC, Galac, Boevé MH, Boroffka SA, Naan EC, IJzer J, Kooistra HS. Evaluation of the oral fludrocortisone suppression test for diagnosing primary hyperaldosteronism in cats. J Vet Intern Med. 2013 Nov-Dec;27(6):1493-9. PubMed PMID: 24627898.

20: Karamouzis I, Berardelli R, Marinazzo E, D'Angelo V, Zinnà D, Minetto MA, Zichi C, Fussotto B, Giordano R, Ghigo E, Arvat E. The acute effect of fludrocortisone on basal and hCRH-stimulated hypothalamic--pituitary--adrenal (HPA) axis in humans. Pituitary. 2013 Sep;16(3):378-85. doi: 10.1007/s11102-012-0435-3. PubMed PMID: 23011321.