Flucytosine | CAS#2022-85-7

Flucytosine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317879

CAS#: 2022-85-7

Description: Flucytosine, a fluorinated pyrimidine analogue, is a synthetic antimycotic drug. It is structurally related to the cytostatic fluorouracil and to floxuridine. Oral flucytosine is indicated for the treatment of serious infections caused by susceptible strains of Candida or Cryptococcus neoformans. It can also be used for the treatment of chromomycosis (chromoblastomycosis), if susceptible strains cause the infection.

Chemical Structure

Flucytosine

CAS# 2022-85-7

Instruction

Theoretical Analysis

MedKoo Cat#: 317879
Name: Flucytosine
CAS#: 2022-85-7
Chemical Formula: C4H4FN3O
Exact Mass: 129.03
Molecular Weight: 129.093
Elemental Analysis: C, 37.22; H, 3.12; F, 14.72; N, 32.55; O, 12.39

Price and Availability

Size	Price	Availability	Quantity
1g	USD 150
2g	USD 250
5g	USD 550
10g	USD 850
20g	USD 1250
50g	USD 1950
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Flucytosine, 5-fluorocytosine, Flucytosin, Ancobon, Ancotil

IUPAC/Chemical Name: 6-amino-5-fluoro-1H-pyrimidin-2-one

InChi Key: XRECTZIEBJDKEO-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)

SMILES Code: O=C1N=CC(F)=C(N)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 129.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yao ZW, Lu X, Shen C, Lin DF. Comparison of flucytosine and fluconazole combined with amphotericin B for the treatment of HIV-associated cryptococcal meningitis: a systematic review and meta-analysis. Eur J Clin Microbiol Infect Dis. 2014 Aug;33(8):1339-44. doi: 10.1007/s10096-014-2074-2. Epub 2014 Feb 20. Review. PubMed PMID: 24550039.

2: Loyse A, Dromer F, Day J, Lortholary O, Harrison TS. Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. J Antimicrob Chemother. 2013 Nov;68(11):2435-44. doi: 10.1093/jac/dkt221. Epub 2013 Jun 20. Review. PubMed PMID: 23788479; PubMed Central PMCID: PMC3797641.

3: Patel R. Antifungal agents. Part I. Amphotericin B preparations and flucytosine. Mayo Clin Proc. 1998 Dec;73(12):1205-25. Review. PubMed PMID: 9868423.

4: Marinová I, Szabadosová V, Brandeburová O, Krcméry V Jr. Rhodotorula spp. fungemia in an immunocompromised boy after neurosurgery successfully treated with miconazole and 5-flucytosine: case report and review of the literature. Chemotherapy. 1994 Jul-Aug;40(4):287-9. Review. PubMed PMID: 8082417.

5: Heidemann H. Prevention of amphotericin B nephrotoxicity: the effect of salt loading and flucytosine. Mykosen Suppl. 1988;2:39-44. Review. PubMed PMID: 3078022.

6: Heidemann H. Prevention of amphotericin B nephrotoxicity: the effect of salt loading and flucytosine. Mycoses. 1988;31 Suppl 2:39-44. Review. PubMed PMID: 3067090.

7: Gerson B. Flucytosine (5-fluorocytosine). Clin Lab Med. 1987 Sep;7(3):541-4. Review. PubMed PMID: 3308294.

8: Bennet JE. Flucytosine. Ann Intern Med. 1977 Mar;86(3):319-21. Review. PubMed PMID: 320931.

9: Polak A. [Flucytosine - a classical partner for combination therapy]. Mycoses. 2002;45 Suppl 3:31-3. Review. German. PubMed PMID: 12690968.

10: Vermes A, Guchelaar HJ, Dankert J. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000 Aug;46(2):171-9. Review. PubMed PMID: 10933638.

11: Viviani MA. Flucytosine--what is its future? J Antimicrob Chemother. 1995 Feb;35(2):241-4. Review. PubMed PMID: 7759388.

12: Francis P, Walsh TJ. Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics, and antifungal therapy. Clin Infect Dis. 1992 Dec;15(6):1003-18. Review. PubMed PMID: 1457631.

13: Paladino JA, Crass RE. Amphotericin B and flucytosine in the treatment of candidal cystitis. Clin Pharm. 1982 Jul-Aug;1(4):349-52. Review. PubMed PMID: 6764395.

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