TA-1887

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522614

CAS#: 1003005-29-5

Description: TA-1887 is a highly potent and selective hSGLT2 inhibitor, with pronounced antihyperglycemic effects in high-fat diet-fed KK (HF-KK) mice. TA-1887 showed favorable pharmacokinetic profiles, and remarkably increases UGE. In addition, oral administration of TA-1887 induced antihyperglycemic effects in HF-KK mice. TA-1887 is a novel chemical class of SGLT2-selective inhibitors for the treatment of type 2 diabetes.


Price and Availability

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10mg
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100mg
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1g
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25mg
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200mg
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2g
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50mg
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500mg
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5g
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TA-1887 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522614
Name: TA-1887
CAS#: 1003005-29-5
Chemical Formula: C24H26FNO5
Exact Mass: 427.1795
Molecular Weight: 427.4724
Elemental Analysis: C, 67.43; H, 6.13; F, 4.44; N, 3.28; O, 18.71


Synonym: TA-1887, TA 1887, TA1887

IUPAC/Chemical Name: (2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluoro-1H-indol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: PXRGAWZIQZMHTH-PFKOEMKTSA-N

InChi Code: InChI=1S/C24H26FNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/m1/s1

SMILES Code: O[C@H]1[C@H](N2C=C(CC3=CC=C(C4CC4)C=C3)C5=C2C=CC=C5F)O[C@H](CO)[C@@H](O)[C@@H]1O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Nomura S, Yamamoto Y, Matsumura Y, Ohba K, Sakamaki S, Kimata H, Nakayama K, Kuriyama C, Matsushita Y, Ueta K, Tsuda-Tsukimoto M. Novel Indole-N-glucoside, TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 Nov 13;5(1):51-5. doi: 10.1021/ml400339b. eCollection 2014 Jan 9. PubMed PMID: 24900773; PubMed Central PMCID: PMC4027614.