Fleroxacin | CAS# 79660-72-3

Fleroxacin
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317876

CAS#: 79660-72-3

Description: Fleroxacin, a quinolone, is a bactericidal drug that inhibits bacterial DNA gyrase and topoisomerase IV. Like other quinolones and fluoroquinolones the compound eradicates bacteria by interfering with DNA replication (bacterial DNA replication, transcription, repair and recombination). Fleroxacin is active against many Gram-positive and Gram-negative bacteria.

Chemical Structure

Fleroxacin

CAS# 79660-72-3

Instruction

Theoretical Analysis

MedKoo Cat#: 317876
Name: Fleroxacin
CAS#: 79660-72-3
Chemical Formula: C17H18F3N3O3
Exact Mass: 369.13
Molecular Weight: 369.338
Elemental Analysis: C, 55.28; H, 4.91; F, 15.43; N, 11.38; O, 13.00

Price and Availability

Size	Price	Availability
500mg	USD 250
1g	USD 280
5g	USD 550	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Fleroxacin, Quinodis, Megalocin, AM-833, Ro 236240

IUPAC/Chemical Name: 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

InChi Key: XBJBPGROQZJDOJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)

SMILES Code: O=C(C1=CN(CCF)C2=C(C=C(F)C(N3CCN(C)CC3)=C2F)C1=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 369.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kostić D. [Fleroxacin--a new quinolone antibiotic]. Vojnosanit Pregl. 1996 Jul-Aug;53(4):311-24. Review. Serbian. PubMed PMID: 9229948.

2: Neu HC, Chin NX. In vitro activity of fleroxacin in combination with other antimicrobial agents. Am J Med. 1993 Mar 22;94(3A):9S-16S. Review. PubMed PMID: 8452190.

3: Nightingale CH. Overview of the pharmacokinetics of fleroxacin. Am J Med. 1993 Mar 22;94(3A):38S-43S. Review. PubMed PMID: 8452184.

4: Gasser TC, Wisard M, Frei R. Oral fleroxacin prophylaxis in transurethral surgery. J Urol. 1996 Jul;156(1):146-8. Review. PubMed PMID: 8648777.

5: Giamarellou H. Fleroxacin in complicated urinary tract infections. Chemotherapy. 1996 Mar;42 Suppl 1:17-27. Review. PubMed PMID: 8861531.

6: Naber KG. Fleroxacin overview. Chemotherapy. 1996 Mar;42 Suppl 1:1-9. Review. PubMed PMID: 8861529.

7: Balfour JA, Todd PA, Peters DH. Fleroxacin. A review of its pharmacology and therapeutic efficacy in various infections. Drugs. 1995 May;49(5):794-850. Review. PubMed PMID: 7601015.

8: Niwicka A. [Fleroxacin--spectrum of activity, pharmacokinetics and clinical use]. Pol Tyg Lek. 1993 Dec 13-27;48(50-52):864-6. Review. Polish. PubMed PMID: 7971511.

9: Stuck AE, Kim DK, Frey FJ. Fleroxacin clinical pharmacokinetics. Clin Pharmacokinet. 1992 Feb;22(2):116-31. Review. PubMed PMID: 1551289.

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