BAY1217389
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206545

CAS#: 1554458-53-5

Description: BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells.


Price and Availability

Size
Price

10mg
Not available
100mg
USD 950
1g
USD 3650
Size
Price

25mg
Not available
200mg
USD 1750
2g
USD 5250
Size
Price

50mg
Not available
500mg
USD 2450
5g
USD 9950

BAY1217389, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206545
Name: BAY1217389
CAS#: 1554458-53-5
Chemical Formula: C27H24F5N5O3
Exact Mass: 561.1799
Molecular Weight: 561.513
Elemental Analysis: C, 57.75; H, 4.31; F, 16.92; N, 12.47; O, 8.55


Synonym: BAY1217389; BAY-1217389; BAY 1217389.

IUPAC/Chemical Name: N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide

InChi Key: WNEILUNVMHVMPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)

SMILES Code: O=C(NC1CC1)C2=CC=C(C3=CN=C4C(NCCC(F)(F)F)=CC(OC5=CC=C(OC)C(F)=C5F)=NN43)C=C2C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wengner AM, Siemeister G, Koppitz M, Schulze V, Kosemund D, Klar U, Stoeckigt
D, Neuhaus R, Lienau P, Bader B, Prechtl S, Raschke M, Frisk AL, von Ahsen O,
Michels M, Kreft B, von Nussbaum F, Brands M, Mumberg D, Ziegelbauer K. Novel
Mps1 kinase inhibitors with potent anti-tumor activity. Mol Cancer Ther. 2016 Feb
1. pii: molcanther.0500.2015. [Epub ahead of print] PubMed PMID: 26832791.