Dezocine HBr

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317598

CAS#: 57236-36-9 (HBr)

Description: Dezocine (Dalgan, WY16225) is an opioid analgesic. First synthesized in 1970, it acts at mu-, delta-, and kappa-opioid receptors. Dezocine acts as a mixed agonist/antagonist of opioid receptors. It is related to other benzomorphans such as pentazocine, with a similar profile of effects that include analgesic action and euphoria. Unlike many other benzomorphans however, it is a silent antagonist of the κ-opioid receptor, and in accordance, does not produce side effects such as dysphoria or hallucinations at any dose.

Chemical Structure

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Dezocine HBr
CAS# 57236-36-9 (HBr)
Instruction

Theoretical Analysis

MedKoo Cat#: 317598
Name: Dezocine HBr
CAS#: 57236-36-9 (HBr)
Chemical Formula: C16H24BrNO
Exact Mass: 245.18
Molecular Weight: 326.278
Elemental Analysis: C, 58.90; H, 7.41; Br, 24.49; N, 4.29; O, 4.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 53648-55-8 (free base)   57236-36-9 (HBr)    

Synonym: DEZOCINE; Dalgan; Wy-16225; Wy 16225; Wy16225; CHEMBL1685; Dezocina; Dezocinum; Dezocine hydrobromide, Dezocine monohydrobromide; MCV 4206; NIH 8834; UM 972.

IUPAC/Chemical Name: (5R,11S,13R)-13-Amino-5-methyl-5,6,7,8,9,10,11,12-octahydro-5,11-methanobenzo[10]annulen-3-ol hydrobromide

InChi Key: HLYQVVMHTCPUKR-VEVZXVCZSA-N

InChi Code: InChI=1S/C16H23NO.BrH/c1-16-8-4-2-3-5-12(15(16)17)9-11-6-7-13(18)10-14(11)16;/h6-7,10,12,15,18H,2-5,8-9,17H2,1H3;1H/t12-,15+,16+;/m0./s1

SMILES Code: OC1=CC=C(C[C@]2([H])CCCCC[C@@]3(C)[C@@H]2N)C3=C1.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 326.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bian X, Zhou R, Yang Y, Li P, Hang Y, Hu Y, Yang L, Wen D. Divergent Effect of Dezocine, Morphine and Sufentanil on Intestinal Motor Function in Rats. Int J Med Sci. 2015 Oct 15;12(11):848-52. doi: 10.7150/ijms.12616. eCollection 2015. PubMed PMID: 26640403; PubMed Central PMCID: PMC4643074.

2: Chen XK, Zhou YP, Zhang X, Xia LP, Li AF, Liu H, Yu HQ. Conscious sedation with midazolam and dezocine for diagnostic flexible bronchoscopy. Eur Rev Med Pharmacol Sci. 2015 Oct;19(19):3688-92. PubMed PMID: 26502859.

3: Zhou X, Zhang C, Wang M, Yu L, Yan M. Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015 Aug 19;10(8):e0136091. doi: 10.1371/journal.pone.0136091. eCollection 2015. PubMed PMID: 26287536; PubMed Central PMCID: PMC4545891.

4: Yu F, Zhou J, Xia S, Xu H, Wang X. Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery. Evid Based Complement Alternat Med. 2015;2015:946194. doi: 10.1155/2015/946194. Epub 2015 Jun 11. PubMed PMID: 26170890; PubMed Central PMCID: PMC4480811.

5: Xu Y, Zhu Y, Wang S, Ren Y, Miao C. Dezocine attenuates fentanyl-induced cough in a dose-dependent manner-a randomized controlled trial. Int J Clin Exp Med. 2015 Apr 15;8(4):6091-6. eCollection 2015. PubMed PMID: 26131209; PubMed Central PMCID: PMC4483907.

6: Ren BX, Zong J, Tang JC, Sun DP, Hui X, Li RQ, Zhang JL, Ji Y. Effects of intravenous analgesia with combined dezocine and butorphanol on postoperative cognitive function in elderly patients. Genet Mol Res. 2015 May 25;14(2):5571-6. doi: 10.4238/2015.May.25.8. PubMed PMID: 26125754.

7: Li S, Min S, Wu B, Tang W. [Application of patient-controlled intravenous analgesia of dezocine combined with sufentanil in burn patients after surgery]. Zhonghua Shao Shang Za Zhi. 2015 Feb;31(1):48-51. Chinese. PubMed PMID: 25876640.

8: Zheng M, Guo Y, Shan S, Yang S. Dezocine for anesthesia and stress reduction in induced abortion. Patient Prefer Adherence. 2015 Mar 3;9:369-72. doi: 10.2147/PPA.S76507. eCollection 2015. PubMed PMID: 25784792; PubMed Central PMCID: PMC4356682.

9: Li X, Xia Q, Li W. Comparison of the effects of dezocine, fentanyl, and placebo on emergence agitation after sevoflurane anesthesia in children. Int J Clin Pharmacol Ther. 2015 Mar;53(3):241-6. doi: 10.5414/CP202184. PubMed PMID: 25669611.

10: Su Z, Zhang Y, Liu Y, An LJ, Liu HL. [The effect of dezocine in prevention of adverse reaction of tracheal extubation in nasal endoscopic operation]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2014 Sep;30(5):394-5, 400. Chinese. PubMed PMID: 25571627.