Decamethonium | CAS#541-22-0 | neuromuscular blocking agent

Decamethonium bromide
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317585

CAS#: 541-22-0

Description: Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle.

Chemical Structure

Decamethonium bromide

CAS# 541-22-0

Instruction

Theoretical Analysis

MedKoo Cat#: 317585
Name: Decamethonium bromide
CAS#: 541-22-0
Chemical Formula: C16H38Br2N2
Exact Mass: 0.00
Molecular Weight: 418.302
Elemental Analysis: C, 45.94; H, 9.16; Br, 38.20; N, 6.70

Price and Availability

Size	Price	Availability
5g	USD 300	2 Weeks
10g	USD 550	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Decamethonium; Decamethonum; Syncurine; DECAMETHONIUM ION; Lopac-D-1260; (DM)Br2

IUPAC/Chemical Name: trimethyl-[10-(trimethylazaniumyl)decyl]azanium bromide

InChi Key: HLXQFVXURMXRPU-UHFFFAOYSA-L

InChi Code: InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code: C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 418.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Brown TC. Aspects of depolarizing neuromuscular blockers: decamethonium and suxamethonium. Paediatr Anaesth. 2013 Sep;23(9):868-70. doi: 10.1111/pan.12122. Epub 2013 Feb 11. PubMed PMID: 23398375.

2: Poulsen H, Hougs W. The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39. Acta Anaesthesiol Scand. 2007 Sep;51(8):1018-42; discussion 1043. PubMed PMID: 17697296.

3: Ball C, Westhorpe R. Muscle relaxants--decamethonium. Anaesth Intensive Care. 2005 Dec;33(6):709. PubMed PMID: 16398373.

4: Macharia R, Patel K, Otto WR, McKinnell IW, Christ B. Decamethonium bromide-mediated inhibition of embryonic muscle development. Anat Embryol (Berl). 2004 Apr;208(1):75-85. Epub 2004 Mar 3. PubMed PMID: 14997390.

5: Lee C, Jones T. Molecular conformation-activity relationship of decamethonium congeners. Br J Anaesth. 2002 May;88(5):692-9. PubMed PMID: 12067008.

6: Redai I, Richards KM, England AJ, Feldman SA. Interaction of decamethonium with hexamethonium or vecuronium in the rat: an isobolographic analysis. Anesth Analg. 1995 Oct;81(4):768-72. PubMed PMID: 7574008.

7: Gu Y, Lee H, Hudson RA. Bis-catechol-substituted redox-reactive analogues of hexamethonium and decamethonium: stimulated affinity-dependent reactivity through iron peroxide catalysis. J Med Chem. 1994 Dec 9;37(25):4417-20. PubMed PMID: 7996555.

8: Effraim KD, Ahmad K. Short communication on erythrocyte membrane stabilization by decamethonium and succinylcholine. Cent Afr J Med. 1994 May;40(5):134-6. PubMed PMID: 7954726.

9: Campkin NT, Hood JR, Feldman SA. Resistance to decamethonium neuromuscular block after prior administration of vecuronium. Anesth Analg. 1993 Jul;77(1):78-80. PubMed PMID: 8100407.

10: Feldman S, Fauvel N. Potentiation and antagonism of vecuronium by decamethonium. Anesth Analg. 1993 Mar;76(3):631-4. PubMed PMID: 8095780.

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Decamethonium bromide featured