Dantrolene
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MedKoo CAT#: 317580

CAS#: 7261-97-4

Description: Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention of malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia. It is also used in the management of neuroleptic malignant syndrome, muscle spasticity (e.g. after strokes, in paraplegia, cerebral palsy, or patients with multiple sclerosis), and 2,4-dinitrophenol poisoning.


Chemical Structure

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Dantrolene
CAS# 7261-97-4

Theoretical Analysis

MedKoo Cat#: 317580
Name: Dantrolene
CAS#: 7261-97-4
Chemical Formula: C14H10N4O5
Exact Mass: 314.07
Molecular Weight: 314.253
Elemental Analysis: C, 53.51; H, 3.21; N, 17.83; O, 25.46

Price and Availability

Size Price Availability Quantity
25mg USD 265 2 weeks
50mg USD 485 2 weeks
100mg USD 650 2 weeks
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Synonym: Dantrolene; Dantroleno; Dantrolenum; Dantrium; Dantrolenum

IUPAC/Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione

InChi Key: OZOMQRBLCMDCEG-VIZOYTHASA-N

InChi Code: InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+

SMILES Code: C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 314.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Britt BA. Dantrolene. Can Anaesth Soc J. 1984 Jan;31(1):61-75. doi: 10.1007/BF03011484. PMID: 6362802.


2: Campos Suárez JM, Escolano Villén F, Catalá Puigbó E, Villar Landeira JM, Sanz Mazó M. Dantroleno sódico [Sodium dantrolene]. Rev Esp Anestesiol Reanim. 1985 Jul-Aug;32(4):179-83. Spanish. PMID: 3901158.


3: Farkhondeh T, Roshanravan B, Shirazi FM, Mehrpour O. Can dantrolene be used in the treatment of cardioglycosides poisonings? Expert Opin Drug Metab Toxicol. 2021 Jan;17(1):1-2. doi: 10.1080/17425255.2021.1843632. Epub 2020 Nov 10. PMID: 33111579.


4: Alkazmi L, Al-Kuraishy HM, Al-Gareeb AI, El-Bouseary MM, Ahmed EA, Batiha GE. Dantrolene and ryanodine receptors in COVID-19: The daunting task and neglected warden. Clin Exp Pharmacol Physiol. 2023 May;50(5):335-352. doi: 10.1111/1440-1681.13756. Epub 2023 Feb 28. PMID: 36732880.


5: Liang L, Wei H. Dantrolene, a treatment for Alzheimer disease? Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):1-5. doi: 10.1097/WAD.0000000000000076. PMID: 25551862; PMCID: PMC4334699.


6: Abou MB, Sun L, Wei H. Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease. Curr Alzheimer Res. 2020;17(4):324-328. doi: 10.2174/1567205017666200522204722. PMID: 32442084; PMCID: PMC7705762.


7: Russell T, Steel A. Dantrolene preparation. Anaesth Intensive Care. 2011 Nov;39(6):1150; author reply 1150-1. PMID: 22165375.


8: Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M. Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis. Biochem Biophys Res Commun. 2022 Oct 8;624:141-145. doi: 10.1016/j.bbrc.2022.07.111. Epub 2022 Aug 2. PMID: 35940127.


9: Ward A, Chaffman MO, Sorkin EM. Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. Drugs. 1986 Aug;32(2):130-68. doi: 10.2165/00003495-198632020-00003. PMID: 3527659.


10: Krause T, Gerbershagen MU, Fiege M, Weisshorn R, Wappler F. Dantrolene--a review of its pharmacology, therapeutic use and new developments. Anaesthesia. 2004 Apr;59(4):364-73. doi: 10.1111/j.1365-2044.2004.03658.x. PMID: 15023108.


11: Pinder RM, Brogden RN, Speight TM, Avery GS. Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity. Drugs. 1977 Jan;13(1):3-23. doi: 10.2165/00003495-197713010-00002. PMID: 318989.


12: Gerbershagen MU, Fiege M, Krause T, Agarwal K, Wappler F. Dantrolen. Pharmakologische und therapeutische Aspekte [Dantrolene. Pharmacological and therapeutic aspects]. Anaesthesist. 2003 Mar;52(3):238-45. German. doi: 10.1007/s00101-003-0461-7. PMID: 12666006.


13: Allen GC. Oral dantrolene. Anaesthesia. 2004 Nov;59(11):1139; author reply 1139-40. doi: 10.1111/j.1365-2044.2004.03979.x. PMID: 15479327.


14: Schneider R, Mitchell D. Dantrolene hepatitis. JAMA. 1976 Apr 12;235(15):1590-1. PMID: 946274.


15: Muehlschlegel S, Sims JR. Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. Neurocrit Care. 2009;10(1):103-15. doi: 10.1007/s12028-008-9133-4. Epub 2008 Aug 12. PMID: 18696266; PMCID: PMC2702250.


16: Samiotis I, Papakonstantinou NA, Dedeilias P, Vasileiadis I, Papalois A, Deftereos S, Kotanidou A. Dantrolene Induces Mitigation of Myocardial Ischemia- Reperfusion Injury by Ryanodine Receptor Inhibition. Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):123-132. doi: 10.1053/j.semtcvs.2021.01.004. Epub 2021 Jan 15. PMID: 33460764.


17: Dantrolene sodium (Dantrium). Drug Ther Bull. 1976 Jul 30;14(16):61-3. PMID: 964132.


18: Harrison GG. Malignant hyperthermia. Dantrolene--dynamics and kinetics. Br J Anaesth. 1988 Feb;60(3):279-86. doi: 10.1093/bja/60.3.279. PMID: 3279988.


19: Hetherington N. Dantrolene. Aust Nurses J. 1992 Mar;21(8):28-9. PMID: 1605782.


20: Hopkins S. Pharmacology: dantrolene sodium. Nurs Mirror. 1980 Dec 11;151(24):30. PMID: 6905140.