WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319586
Description: Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo.
MedKoo Cat#: 319586
Name: Olumacostat glasaretil
Chemical Formula: C26H43NO7
Exact Mass: 481.304
Molecular Weight: 481.63
Elemental Analysis: C, 64.84; H, 9.00; N, 2.91; O, 23.25
Synonym: Olumacostat glasaretil; DRM01B; DRM-01B; DRM 01B.
IUPAC/Chemical Name: 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate
InChi Key: FYJLDICZGDFWKP-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H43NO7/c1-4-6-7-8-9-10-11-12-13-14-15-16-19-32-25-18-17-22(34-25)26(30)33-21-23(28)27(3)20-24(29)31-5-2/h17-18H,4-16,19-21H2,1-3H3
SMILES Code: O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O
Inhibition of ACC activity in the sebaceous glands is designed to substantially impact sebum production since over 80% of human sebum components contain fatty acids. OG inhibits de novo lipid synthesis in primary and transformed human sebocytes.
1: Bissonnette R, Poulin Y, Drew J, Hofland H, Tan J. Olumacostat glasaretil, a
novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa,
multicenter, randomized, vehicle-controlled study. J Am Acad Dermatol. 2017
Jan;76(1):33-39. doi: 10.1016/j.jaad.2016.08.053. Epub 2016 Oct 28. PubMed PMID:
2: Hunt DW, Winters GC, Brownsey RW, Kulpa JE, Gilliland KL, Thiboutot DM,
Hofland HE. Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase
Inhibitor Olumacostat Glasaretil. J Invest Dermatol. 2017 Mar 1. pii:
S0022-202X(17)30186-0. doi: 10.1016/j.jid.2016.12.031. [Epub ahead of print]
PubMed PMID: 28259683.