Acebilustat
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319573

CAS#: 943764-99-6

Description: Acebilustat, also known as ZK322, is a potent and selective leukotriene A4 hydrolase inhibitor.


Price and Availability

Size
Price

25mg
USD 350
200mg
USD 1650
2g
USD 4950
Size
Price

50mg
USD 550
500mg
USD 2650
5g
USD 11450
Size
Price

100mg
USD 950
1g
USD 3250
10g
USD 18750

Acebilustat, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319573
Name: Acebilustat
CAS#: 943764-99-6
Chemical Formula: C29H27N3O4
Exact Mass: 481.2002
Molecular Weight: 481.55
Elemental Analysis: C, 72.33; H, 5.65; N, 8.73; O, 13.29


Synonym: ZK322; ZK-322; ZK 322; CTX-4430; EP-501; CTX4430; EP501; CTX 4430; EP 501; Acebilustat, CAS#943764-99-6

IUPAC/Chemical Name: 4-(((1S,4S)-5-(4-(4-(oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid

InChi Key: GERJIEKMNDGSCS-DQEYMECFSA-N

InChi Code: InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1

SMILES Code: O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Elborn JS, Horsley A, MacGregor G, Bilton D, Grosswald R, Ahuja S, Springman
EB. Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients
with Cystic Fibrosis. Clin Transl Sci. 2017 Jan;10(1):28-34. doi:
10.1111/cts.12428. PubMed PMID: 27806191.

2: Elborn JS, Bhatt L, Grosswald R, Ahuja S, Springman EB. Phase I Studies of
Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A
Induction. Clin Transl Sci. 2017 Jan;10(1):20-27. doi: 10.1111/cts.12426. PubMed
PMID: 27792868.