AZD0156
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206501

CAS#: 1821428-35-6

Description: AZD0156 is an orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 3250
Size
Price

25mg
USD 250
200mg
USD 1050
2g
USD 4850
Size
Price

50mg
USD 450
500mg
USD 1950
5g
USD 8650

AZD0156, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 400mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206501
Name: AZD0156
CAS#: 1821428-35-6
Chemical Formula: C26H31N5O3
Exact Mass: 461.2427
Molecular Weight: 461.566
Elemental Analysis: C, 67.66; H, 6.77; N, 15.17; O, 10.40


Synonym: AZD0156; AZD-0156; AZD 0156.

IUPAC/Chemical Name: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one

InChi Key: AOTRIQLYUAFVSC-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3

SMILES Code: O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490