WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206501
Description: AZD0156 is an orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy.
MedKoo Cat#: 206501
Chemical Formula: C26H31N5O3
Exact Mass: 461.2427
Molecular Weight: 461.566
Elemental Analysis: C, 67.66; H, 6.77; N, 15.17; O, 10.40
Synonym: AZD0156; AZD-0156; AZD 0156.
IUPAC/Chemical Name: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one
InChi Key: AOTRIQLYUAFVSC-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3
SMILES Code: O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3