ACY-775
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MedKoo CAT#: 206493

CAS#: 1375466-18-4

Description: ACY-775 is a potent and selective HDAC6 inhbiitor. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 shares the antidepressant-like properties of other HDAC inhibitors, such as SAHA and MS-275, in the tail suspension test and social defeat paradigm.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
Size
Price

25mg
USD 250
200mg
USD 1050
Size
Price

50mg
USD 450
5g
Ask price

ACY-775, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order >5g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206493
Name: ACY-775
CAS#: 1375466-18-4
Chemical Formula: C17H19FN4O2
Exact Mass: 330.1492
Molecular Weight: 330.36
Elemental Analysis: C, 61.81; H, 5.80; F, 5.75; N, 16.96; O, 9.69


Synonym: ACY-775; ACY 775; ACY775.

IUPAC/Chemical Name: 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide

InChi Key: IYBURCQQEUNLDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19FN4O2/c18-14-6-4-5-13(9-14)17(7-2-1-3-8-17)21-16-19-10-12(11-20-16)15(23)22-24/h4-6,9-11,24H,1-3,7-8H2,(H,22,23)(H,19,20,21)

SMILES Code: O=C(C1=CN=C(NC2(C3=CC=CC(F)=C3)CCCCC2)N=C1)NO


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH,
Jones S, Berton O. Antidepressant-like properties of novel HDAC6-selective
inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014
Jan;39(2):389-400. doi: 10.1038/npp.2013.207. Epub 2013 Aug 19. PubMed PMID:
23954848; PubMed Central PMCID: PMC3870780.

2: Mithraprabhu S, Khong T, Jones SS, Spencer A. Histone deacetylase (HDAC)
inhibitors as single agents induce multiple myeloma cell death principally
through the inhibition of class I HDAC. Br J Haematol. 2013 Aug;162(4):559-62.
doi: 10.1111/bjh.12388. Epub 2013 May 21. PubMed PMID: 23692150.