Vadadustat
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319561

CAS#: 1000025-07-9

Description: Vadadustat, also known as AKB-6548 and PG-1016548, is a potent Hypoxia-inducible factor-proline dioxygenase inhibitor. AKB-6548 works by inhibiting hypoxia inducible factor-prolyl hydroxylase (HIP-PH), leading to stabilization and increased levels of HIFα. In turn HIFα improves production of hemoglobin and red blood cells (RBCs), while maintaining normal levels of erythropoietin (EPO) in patients. We believe this differentiated mechanism of action has the potential to be safer than that of injectable recombinant erythropoietin stimulating agents (rESAs), avoiding supra-physiological levels of EPO and saturation of EPO receptors for prolonged periods of time.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2250
Size
Price

25mg
USD 250
200mg
USD 950
2g
USD 3850
Size
Price

50mg
USD 450
500mg
USD 1450
5g
USD 5850

Vadadustat purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 3g may be 2 weeks.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 319561
Name: Vadadustat
CAS#: 1000025-07-9
Chemical Formula: C14H11ClN2O4
Exact Mass: 306.0407
Molecular Weight: 306.7
Elemental Analysis: C, 54.83; H, 3.62; Cl, 11.56; N, 9.13; O, 20.87


Synonym: AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506; Vadadustat

IUPAC/Chemical Name: (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycine

InChi Key: JGRXMPYUTJLTKT-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)

SMILES Code: O=C(O)CNC(C1=NC=C(C2=CC=CC(Cl)=C2)C=C1O)=O


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Beuck S, Schänzer W, Thevis M. Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis. Drug Test Anal. 2012 Nov;4(11):830-45. doi: 10.1002/dta.390. Epub 2012 Feb 24. Review. PubMed PMID: 22362605.