Ralinepag

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319555

CAS#: 1187856-49-0

Description: Ralinepag, also known as APD-811, is an orally available agonist of the prostacyclin (IP) receptor, is an investigational drug candidate internally discovered and developed by Arena and intended for the treatment of vasospastic diseases, such as Pulmonary Arterial Hypertension. Ralinepag has the potential to mimic prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, which elicits a potent vasodilation and inhibition of platelet aggregation when binding to this receptor.


Price and Availability

Size
Price

1g
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Size
Price

2g
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Size
Price

5g
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Ralinepag is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319555
Name: Ralinepag
CAS#: 1187856-49-0
Chemical Formula: C23H26ClNO5
Exact Mass: 431.15
Molecular Weight: 431.91
Elemental Analysis: C, 63.96; H, 6.07; Cl, 8.21; N, 3.24; O, 18.52


Synonym: APD-811; APD 811; APD811; Ralinepag

IUPAC/Chemical Name: 2-(((1r,4r)-4-((((4-chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetic acid

InChi Key: NPDKXVKJRHPDQT-IYARVYRRSA-N

InChi Code: O=C(COC[C@H]1CC[C@@H](CC1)COC(N(C2=CC=CC=C2)C3=CC=C(C=C3)Cl)=O)O

SMILES Code: O=C(O)COC[C@H]1CC[C@H](COC(N(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)=O)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490