UK-356202

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206486

CAS#: 223671-94-1

Description: UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, including breast, ovarian, and pancreatic cancer. uPA is a valuable oncology target.

Chemical Structure

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UK-356202
CAS# 223671-94-1
Instruction

Theoretical Analysis

MedKoo Cat#: 206486
Name: UK-356202
CAS#: 223671-94-1
Chemical Formula: C17H13ClN4O2
Exact Mass: 340.07
Molecular Weight: 340.767
Elemental Analysis: C, 59.92; H, 3.85; Cl, 10.40; N, 16.44; O, 9.39

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Synonym: UK-356202; UK356202; UK 356202; UK-356,202; UK356,202; UK 356,202

IUPAC/Chemical Name: 3-(4-chloro-1-guanidinoisoquinolin-7-yl)benzoic acid

InChi Key: UXNWIRHZMHGOCE-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13ClN4O2/c18-14-8-21-15(22-17(19)20)13-7-10(4-5-12(13)14)9-2-1-3-11(6-9)16(23)24/h1-8H,(H,23,24)(H4,19,20,21,22)

SMILES Code: O=C(O)C1=CC=CC(C2=CC3=C(C=C2)C(Cl)=CN=C3NC(N)=N)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bayliss MA, Venn RF, Edgington AM, Webster R, Walker DK. Determination of a potent urokinase-type plasminogen activator, UK-356,202, in plasma at pg/mL levels using column-switching HPLC and fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):121-6. doi: 10.1016/j.jchromb.2008.11.038. Epub 2008 Dec 3. PubMed PMID: 19119083.

2: Barber CG, Dickinson RP, Fish PV. Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. PubMed PMID: 15149680.