Malonoben
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319530

CAS#: 10537-47-0

Description: Malonoben, also known as AG-17 or Tyrphostin-9, is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.


Price and Availability

Size
Price

100mg
USD 750
1g
USD 3250
Size
Price

200mg
USD 1250
2g
USD 4850
Size
Price

500mg
USD 2250
5g
USD 6450

Malonoben (AG-17), purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319530
Name: Malonoben
CAS#: 10537-47-0
Chemical Formula: C18H22N2O
Exact Mass: 282.17321
Molecular Weight: 282.387
Elemental Analysis: C, 76.56; H, 7.85; N, 9.92; O, 5.67


Synonym: Tyrphostin-9; Tyrphostin 9; Tyrphostin 9; Malonoben; Tyrphostin AG-17; SF 6847; GCP 5126; RG-50872; NSC 242557.

IUPAC/Chemical Name: 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-propanedinitrile

InChi Key: MZOPWQKISXCCTP-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

SMILES Code: N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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8: Martín A, Martínez-Espada N, Mena M, Pérez-Redondo A, Yélamos C. Copper(I) and silver(I) complexes supported by the tridentate [{Ti(η(5)-C5Me5)(μ-NH)}3(μ3-N)] metalloligand. Inorg Chem. 2013 Jan 18;52(2):918-30. doi: 10.1021/ic302113k. Epub 2012 Dec 26. PubMed PMID: 23268605.

9: Iqbal S, Zhang S, Driss A, Liu ZR, Kim HR, Wang Y, Ritenour C, Zhau HE, Kucuk O, Chung LW, Wu D. PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells. PLoS One. 2012;7(1):e30764. doi: 10.1371/journal.pone.0030764. Epub 2012 Jan 20. PubMed PMID: 22276222; PubMed Central PMCID: PMC3262835.

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11: Tang PH, Wu TM, Yen TW, Lai SK, Hsu PJ. Comparative study of cluster Ag17Cu2 by instantaneous normal mode analysis and by isothermal Brownian-type molecular dynamics simulation. J Chem Phys. 2011 Sep 7;135(9):094302. doi: 10.1063/1.3628669. PubMed PMID: 21913758.

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