O4I2
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MedKoo CAT#: 522505

CAS#: 165682-93-9

Description: O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation. The octamer-binding transcription factor 4 (Oct3/4) is a master gene in the transcriptional regulatory network of pluripotent cells. Repression of Oct3/4 in embryonic stem cells (ESCs) is associated with cell differentiation and loss of pluripotency, whereas forced overexpression in cooperation with other transcriptional factors, such as Nanog, Sox2, and Lin28, can reprogram somatic cells back into pluripotent cells, termed induced pluripotent stem cells (iPSCs).


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 650
2g
USD 3850
Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 5850
Size
Price

100mg
USD 450
1g
USD 2450

O4I2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522505
Name: O4I2
CAS#: 165682-93-9
Chemical Formula: C12H11ClN2O2S
Exact Mass: 282.02298
Molecular Weight: 282.742
Elemental Analysis: C, 50.98; H, 3.92; Cl, 12.54; N, 9.91; O, 11.32; S, 11.34


Synonym: O4I2; O-4I2; O4I-2.

IUPAC/Chemical Name: ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate

InChi Key: ULUBAPWNHROTEU-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)

SMILES Code: O=C(C1=CSC(NC2=CC=C(Cl)C=C2)=N1)OCC


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, Göhring A,
Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Utikal J, Mrowka
R, Wölfl S. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives
Are Potent Inducers of Oct3/4. J Med Chem. 2015 Aug 13;58(15):5742-50. doi:
10.1021/acs.jmedchem.5b00226. Epub 2015 Jul 23. PubMed PMID: 26143659.