LY2409881
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407218

CAS#: 946518-61-2

Description: LY2409881 is a potent and selective IKK2 inhibitor. LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs.


Chemical Structure

img
LY2409881
CAS# 946518-61-2

Theoretical Analysis

MedKoo Cat#: 407218
Name: LY2409881
CAS#: 946518-61-2
Chemical Formula: C24H29ClN6OS
Exact Mass: 484.18
Molecular Weight: 485.047
Elemental Analysis: C, 59.43; H, 6.03; Cl, 7.31; N, 17.33; O, 3.30; S, 6.61

Price and Availability

Size Price Availability Quantity
50mg USD 450 2 weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 6450 2 Weeks
Bulk inquiry

Related CAS #: 946518-61-2   946518-60-1 (3HCl)  

Synonym: LY2409881; LY-2409881; LY 2409881.

IUPAC/Chemical Name: 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide

InChi Key: BNFAYJPQCPZQND-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H29ClN6OS/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29)

SMILES Code: O=C(C1=C(C=C(C2=NC(NCCCN3CCN(CC3)C)=NC=C2Cl)S4)C4=CC=C1)NC5CC5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 485.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Deng C, Lipstein M, Rodriguez R, Serrano XO, McIntosh C, Tsai WY, Wasmuth AS,
Jaken S, O'Connor OA. The novel IKK2 inhibitor LY2409881 potently synergizes with
histone deacetylase inhibitors in preclinical models of lymphoma through the
downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45. doi:
10.1158/1078-0432.CCR-14-0384. Epub 2014 Oct 29. PubMed PMID: 25355930.