BMS-795311
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MedKoo CAT#: 522501

CAS#: 939390-99-5

Description: BMS-795311 is a potent CETP inhibitor that maximally inhibited cholesteryl ester (CE) transfer activity at an oral dose of 1 mg/kg in human ETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to torcetrapib in moderately-fat fed hamsters. Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that is responsible for transporting neutral lipids such as cholesteryl esters (CEs) and triglycerides (TGs) among various classes of lipoproteins including HDL, LDL, and very low density lipoprotein (VLDL).2 Physiologically, CETP facilitates the transfer of CE from HDL to LDL and VLDL in exchange for TG, leading to decreased HDL-C levels and increased LDL-C levels.

Chemical Structure

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BMS-795311
CAS# 939390-99-5
Instruction

Theoretical Analysis

MedKoo Cat#: 522501
Name: BMS-795311
CAS#: 939390-99-5
Chemical Formula: C34H23F10NO3
Exact Mass: 683.15
Molecular Weight: 683.546
Elemental Analysis: C, 59.74; H, 3.39; F, 27.79; N, 2.05; O, 7.02

Price and Availability

Size Price Availability Quantity
10mg USD 530 2 Weeks
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Synonym: BMS-795311; BMS 795311; BMS795311.

IUPAC/Chemical Name: (R)-N-(1-(3-cyclopropoxy-4-fluorophenyl)-1-(3-fluoro-5-(2,2,3,3-tetrafluoropropanoyl)phenyl)-2-phenylethyl)-4-fluoro-3-(trifluoromethyl)benzamide

InChi Key: VHVGQTQWTDTENQ-JGCGQSQUSA-N

InChi Code: InChI=1S/C34H23F10NO3/c35-23-13-20(29(46)33(40,41)31(38)39)12-22(15-23)32(17-18-4-2-1-3-5-18,21-7-11-27(37)28(16-21)48-24-8-9-24)45-30(47)19-6-10-26(36)25(14-19)34(42,43)44/h1-7,10-16,24,31H,8-9,17H2,(H,45,47)/t32-/m1/s1

SMILES Code: FC1=CC=C(C=C1OC2CC2)[C@](CC3=CC=CC=C3)(C4=CC(C(C(C(F)F)(F)F)=O)=CC(F)=C4)NC(C5=CC(C(F)(F)F)=C(C=C5)F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 683.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME. Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311). J Med Chem. 2015 Nov 17. [Epub ahead of print] PubMed PMID: 26524347.