Bambuterol Hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317309

CAS#: 81732-46-9

Description: Bambuterol Hydrochloride is a long acting beta-adrenoceptor agonist used in the treatment of asthma. Bambuterol Hydrochloride acts as a bronchodilator. It inhibits plasma BChE (cholinesterase) during metabolism prolongs suxamethonium-induced neuromuscular blockade.


Price and Availability

Size
Price

5mg
USD 50
50mg
USD 80
500mg
USD 150
5g
USD 950
50g
Ask price
Size
Price

10mg
USD 60
100mg
USD 90
1g
USD 250
10g
USD 1650
100g
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Size
Price

25mg
USD 70
200mg
USD 120
2g
USD 450
20g
USD 2750

Bambuterol Hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317309
Name: Bambuterol Hydrochloride
CAS#: 81732-46-9
Chemical Formula: C18H30ClN3O5
Exact Mass:
Molecular Weight: 403.9
Elemental Analysis: C, 53.53; H, 7.49; Cl, 8.78; N, 10.40; O, 19.81


Synonym: Bambuterol Hydrochloride; UNII-Y1850G1OVC; Bambuterol HCl; CHEBI:59167;DSSTox_CID_25515

IUPAC/Chemical Name: [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate;hydrochloride

InChi Key: LBARATORRVNNQM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H

SMILES Code: CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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Impact of Ternary Solvent System in Stability-Indicating Assay Method of
Bambuterol: Design of Experiments Approach. J Chromatogr Sci. 2015 Sep 10. pii:
bmv137. [Epub ahead of print] PubMed PMID: 26362115.

2: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of
β-agonists in feed and animal body fluid and tissues using ultra-high performance
liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry
combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi:
10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PubMed PMID: 26304337.

3: Wang Y, Qin F, Xiong Z, Fu X, Ma C. An LC-MS/MS method for simultaneous
determination of trantinterol and its major metabolite in rat plasma and its
application to a comparative pharmacokinetic study. J Chromatogr B Analyt Technol
Biomed Life Sci. 2015 Sep 1;1000:163-8. doi: 10.1016/j.jchromb.2015.07.022. Epub
2015 Jul 17. PubMed PMID: 26245359.

4: Ye Y, Xu H, Quan L, Zhu L, Zeng J, Zhou T, Zou C, Cheng Q, Bu S, Tan W. The
Lipid-lowering Effects of R-bambuterol in Healthy Chinese Volunteers: A
Randomized Phase I Clinical Study. EBioMedicine. 2015 Feb 13;2(4):356-64. doi:
10.1016/j.ebiom.2015.02.006. eCollection 2015 Apr. PubMed PMID: 26137575; PubMed
Central PMCID: PMC4485901.

5: Zhou T, Liu S, Zhao T, Zeng J, He M, Xu B, Qu S, Xu L, Tan W. Chiral analysis
of bambuterol, its intermediate and active drug in human plasma by liquid
chromatography-tandem mass spectrometry: Application to a pharmacokinetic study.
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 1;997:38-44. doi:
10.1016/j.jchromb.2015.05.024. Epub 2015 May 19. PubMed PMID: 26092775.

6: Li Q, Wang J, Zheng YY, Yang L, Zhang Y, Bian L, Zheng J, Li Z, Zhao X, Zhang
Y. Comparison of zonal elution and nonlinear chromatography in determination of
the interaction between seven drugs and immobilised β(2)-adrenoceptor. J
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May 14. PubMed PMID: 26002106.

7: Lamie NT. Application of a new spectrophotometric method manipulating ratio
spectra for determination of bambuterol hydrochloride in the presence of its
degradation product terbutaline. Guang Pu Xue Yu Guang Pu Fen Xi. 2015
Jan;35(1):151-6. PubMed PMID: 25993839.

8: Huang J, Lu Y, Wan Q, Zhang M, Pei Q, Zhang M, Liu G, Yang G. Simultaneous
Determination of Trantinterol and One of Its Major Metabolites, 1-Carbonyl
Trantinterol, in Human Plasma by LC-MS-MS. J Chromatogr Sci. 2015
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25689985.

9: Pistolozzi M, Du H, Wei H, Tan W. Stereoselective inhibition of human
butyrylcholinesterase by the enantiomers of bambuterol and their intermediates.
Drug Metab Dispos. 2015 Mar;43(3):344-52. doi: 10.1124/dmd.114.060251. Epub 2014
Dec 11. PubMed PMID: 25504505.

10: Gao F, Wu M, Zhang Y, Wang G, Wang Q, He P, Fang Y. Sensitive determination
of four β(2)-agonists in pig feed by capillary electrophoresis using on-line
sample preconcentration with contactless conductivity detection. J Chromatogr B
Analyt Technol Biomed Life Sci. 2014 Oct 12;973C:29-32. doi:
10.1016/j.jchromb.2014.10.004. [Epub ahead of print] PubMed PMID: 25464091.

11: Guan S, Hu CY, He MY, Yang YY, Tang YX, Chen JD, Huang LJ, Tan W. Comparative
pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol
after single-dose intravenous, oral administration in rats and beagle dogs. Eur J
Drug Metab Pharmacokinet. 2014 Oct 4. [Epub ahead of print] PubMed PMID:
25281237.

12: Petrov KA, Girard E, Nikitashina AD, Colasante C, Bernard V, Nurullin L,
Leroy J, Samigullin D, Colak O, Nikolsky E, Plaud B, Krejci E. Schwann cells
sense and control acetylcholine spillover at the neuromuscular junction by α7
nicotinic receptors and butyrylcholinesterase. J Neurosci. 2014 Sep
3;34(36):11870-83. doi: 10.1523/JNEUROSCI.0329-14.2014. PubMed PMID: 25186736.

13: Zhou T, Cheng Q, Zou C, Zhao T, Liu S, Pistolozzi M, Tan E, Xu L, Tan W.
Simultaneous determination of bambuterol and its two major metabolites in human
plasma by hydrophilic interaction ultra-performance liquid chromatography-tandem
mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep
15;967:225-34. doi: 10.1016/j.jchromb.2014.07.022. Epub 2014 Jul 21. PubMed PMID:
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14: Wu K, Guo L, Xu W, Xu H, Aguilar ZP, Xu G, Lai W, Xiong Y, Wan Y. Sulfonated
polystyrene magnetic nanobeads coupled with immunochromatographic strip for
clenbuterol determination in pork muscle. Talanta. 2014 Nov;129:431-7. doi:
10.1016/j.talanta.2014.06.007. Epub 2014 Jun 14. PubMed PMID: 25127616.

15: Zhou T, Zhao T, Cheng Q, Liu S, Xu L, Tan W. A sensitive LC-MS/MS method for
simultaneous determination of R-bambuterol and its active metabolite
R-terbutaline in human plasma and urine with application to a clinical
pharmacokinetic study. Biomed Chromatogr. 2014 Jul;28(7):994-1002. doi:
10.1002/bmc.3107. Epub 2013 Dec 20. PubMed PMID: 24357101.

16: Kong D, Chen H, Chen W, Liu S, Wang H, Wu T, Lu H, Kong Q, Huang X, Lu Z.
Gene expression profiling analysis of hepatocellular carcinoma. Eur J Med Res.
2013 Nov 14;18:44. doi: 10.1186/2047-783X-18-44. Retraction in: Eur J Med Res.
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17: Suo DC, Zhao GL, Wang PL, Su XO. Simultaneous determination of β-agonists and
psychiatric drugs in feeds by LC-MS-MS. J Chromatogr Sci. 2014 Aug;52(7):604-8.
doi: 10.1093/chromsci/bmt084. Epub 2013 Jun 30. PubMed PMID: 23817171.

18: Cai Q, Wu J, Qian Z, Peng Y, Cai J, Du Z. [Determination of nine beta-agonist
residues in pig tissues by liquid chromatography-tandem mass spectrometry
combining with library search]. Se Pu. 2013 Mar;31(3):200-5. Chinese. PubMed
PMID: 23785990.

19: Yanamandra R, Vadla CS, Puppala UM, Patro B, Murthy YL, Parimi AR.
Development and Validation of a Rapid RP-UPLC Method for the Simultaneous
Estimation of Bambuterol Hydrochloride and Montelukast Sodium from Tablets.
Indian J Pharm Sci. 2012 Mar;74(2):116-21. doi: 10.4103/0250-474X.103841. PubMed
PMID: 23325991; PubMed Central PMCID: PMC3546327.

20: Malmborg J, Ploeger BA. Predicting human exposure of active drug after oral
prodrug administration, using a joined in vitro/in silico-in vivo extrapolation
and physiologically-based pharmacokinetic modeling approach. J Pharmacol Toxicol
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Dec 29. PubMed PMID: 23280406.