Baclofen
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317307

CAS#: 1134-47-0

Description: Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission.


Price and Availability

Size
Price

100mg
USD 80
1g
USD 150
10g
USD 650
100g
Ask price
Size
Price

200mg
USD 90
2g
USD 250
20g
USD 950
200g
Ask price
Size
Price

500mg
USD 120
5g
USD 450
50g
USD 1650
500g
Ask price

Baclofen purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317307
Name: Baclofen
CAS#: 1134-47-0
Chemical Formula: C10H12ClNO2
Exact Mass: 213.05566
Molecular Weight: 213.66
Elemental Analysis: C, 56.21; H, 5.66; Cl, 16.59; N, 6.56; O, 14.98


Synonym: Baclofen; Lioresal, Liofen, Gablofen; Baclon; Kemstro

IUPAC/Chemical Name: 4-amino-3-(4-chlorophenyl)butanoic acid

InChi Key: KPYSYYIEGFHWSV-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

SMILES Code: O=C(O)CC(C1=CC=C(Cl)C=C1)CN


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hasnat MJ, Rice JE. Intrathecal baclofen for treating spasticity in children
with cerebral palsy. Cochrane Database Syst Rev. 2015 Nov 13;11:CD004552. [Epub
ahead of print] Review. PubMed PMID: 26563961.

2: Ingale H, Ughratdar I, Muquit S, Moussa AA, Vloeberghs MH. Selective dorsal
rhizotomy as an alternative to intrathecal baclofen pump replacement in GMFCS
grades 4 and 5 children. Childs Nerv Syst. 2015 Nov 9. [Epub ahead of print]
PubMed PMID: 26552383.

3: Hajj R, Milet A, Toulorge D, Cholet N, Laffaire J, Foucquier J, Robelet S,
Mitry R, Guedj M, Nabirotchkin S, Chumakov I, Cohen D. Combination of acamprosate
and baclofen as a promising therapeutic approach for Parkinson's disease. Sci
Rep. 2015 Nov 6;5:16084. doi: 10.1038/srep16084. PubMed PMID: 26542636.

4: Scarpellini E, Boecxstaens V, Broers C, Vos R, Pauwels A, Tack J. Effect of
baclofen on gastric acid pocket in subjects with gastroesophageal reflux disease
symptoms. Dis Esophagus. 2015 Nov 6. doi: 10.1111/dote.12443. [Epub ahead of
print] PubMed PMID: 26541138.

5: Nahar LK, Cordero RE, Nutt D, Lingford-Hughes A, Turton S, Durant C, Wilson S,
Paterson S. Validated Method for the Quantification of Baclofen in Human Plasma
Using Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry.
J Anal Toxicol. 2015 Nov 4. pii: bkv125. [Epub ahead of print] PubMed PMID:
26538544.

6: Zheng K, Brodsky JB. Spinal Surgery and Abrupt Intrathecal Baclofen
Withdrawal. A A Case Rep. 2015 Nov 1;5(9):160-1. doi:
10.1213/XAA.0000000000000215. PubMed PMID: 26528702.

7: Clearfield JS, Nelson ME, McGuire J, Rein LE, Tarima S. Intrathecal Baclofen
Dosing Regimens: A Retrospective Chart Review. Neuromodulation. 2015 Oct 30. doi:
10.1111/ner.12361. [Epub ahead of print] PubMed PMID: 26517855.

8: Sayer C, Lumsden DE, Perides S, Tustin K, Bassi S, Lin JP, Kaminska M.
Intrathecal baclofen trials: complications and positive yield in a pediatric
cohort. J Neurosurg Pediatr. 2015 Oct 30:1-6. [Epub ahead of print] PubMed PMID:
26517061.

9: Shibata A, Yamamoto M, Watanabe Y, Terashima H, Kashii H, Kubota M, Morota N.
[Scintigraphic imaging in the diagnosis of failed intrathecal baclofen therapy: a
case report of a 7-year-old boy with ventriculoperitoneal shunt]. No To Hattatsu.
2015 Sep;47(5):367-71. Japanese. PubMed PMID: 26502655.

10: McCormick ZL, Chu SK, Binler D, Neudorf D, Mathur SN, Lee J, Marciniak C.
Intrathecal versus Oral Baclofen; a Matched Cohort Study of Spasticity, Pain,
Sleep, Fatigue and Quality of Life. PM R. 2015 Oct 20. pii:
S1934-1482(15)01065-5. doi: 10.1016/j.pmrj.2015.10.005. [Epub ahead of print]
PubMed PMID: 26498518.

11: Medical Cost Impact of Intrathecal Baclofen Therapy for Severe Spasticity.
Neuromodulation. 2015 Oct;18(7):650. doi: 10.1111/ner.12355. PubMed PMID:
26477603.

12: Brown JW, Moeller A, Schmidt M, Turner SC, Nimmrich V, Ma J, Rueter LE, van
der Kam E, Zhang M. Anticonvulsant effects of structurally diverse GABA(B)
positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison
to baclofen and utility as a pharmacodynamic screening model. Neuropharmacology.
2015 Oct 20;101:358-369. doi: 10.1016/j.neuropharm.2015.10.009. [Epub ahead of
print] PubMed PMID: 26471422.

13: Weibel S, Lalanne L, Riegert M, Bertschy G. Efficacy of High-Dose Baclofen
for Alcohol Use Disorder and Comorbid Bulimia: A Case Report. J Dual Diagn. 2015
Oct 12:0. [Epub ahead of print] PubMed PMID: 26457456.

14: Salte K, Lea G, Franek M, Vaculin S. Baclofen reversed thermal place
preference in rats with chronic constriction injury. Physiol Res. 2015 Oct 8.
[Epub ahead of print] PubMed PMID: 26447518.

15: Chaignot C, Weill A, Ricordeau P, Alla F. [Use in France of Baclofen for
Alcohol Dependence from 2007 to 2013: Cohort Study Based on the Databases SNIIRAM
and PMSI]. Therapie. 2015 Sep-Oct;70(5):443-53. doi: 10.2515/therapie/2015027.
Epub 2015 Jun 26. French. PubMed PMID: 26423143.

16: Baclofen and pregnancy: birth defects and withdrawal symptoms. Prescrire Int.
2015 Sep;24(163):214. PubMed PMID: 26417633.

17: Cleophax C, Goncalves A, Chasport C, de Beaugrenier E, Labat L, Declèves X,
Mégarbane B. Usefulness of plasma drug monitoring in severe baclofen poisoning.
Clin Toxicol (Phila). 2015 Nov;53(9):1-2. doi: 10.3109/15563650.2015.1088158.
PubMed PMID: 26415080.

18: Liu L, Li CJ, Lu Y, Zong XG, Luo C, Sun J, Guo LJ. Baclofen mediates
neuroprotection on hippocampal CA1 pyramidal cells through the regulation of
autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015 Sep 28;5:14474.
doi: 10.1038/srep14474. PubMed PMID: 26412641; PubMed Central PMCID: PMC4585985.

19: Sechrist C, Kinsman S, Cain N. Profound Bradycardia After Intrathecal
Baclofen Injection in a Patient With Hydranencephaly. Pediatr Neurol. 2015 Aug
28. pii: S0887-8994(15)00419-1. doi: 10.1016/j.pediatrneurol.2015.08.010. [Epub
ahead of print] PubMed PMID: 26411756.

20: Reichmuth P, Blanc AL, Tagan D. Unintentional baclofen intoxication in the
management of alcohol use disorder. BMJ Case Rep. 2015 Sep 22;2015. pii:
bcr2015212187. doi: 10.1136/bcr-2015-212187. PubMed PMID: 26396128.