Candoxatril

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317365

CAS#: 118785-03-8

Description: Candoxatril is the orally active prodrug of candoxatrilat (UK-73967) human neutral endopeptidase (Neprilysin) as the neutral endopeptidase 24.11 complexed (RB-101) with phosphoramidon degrades and inactivates a number of bioactive peptides. Two multiply connected folding domains of the neutral endopeptidase locus splicing of exons 1, 2a, or 2b to the common exon 3 composed of 24 exons of the human CALLA/NEP gene containing the active site, it is known as peptidase family M13 the gluzincins a faint but significant structural relationship of the metzincins to the thermolysin-like enzymes, Zincin is the simplest descriptor of biological space.


Price and Availability

Size
Price

1g
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Size
Price

2g
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Size
Price

5g
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Candoxatril purity 98% is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317365
Name: Candoxatril
CAS#: 118785-03-8
Chemical Formula: C29H41NO7
Exact Mass: 515.2883
Molecular Weight: 515.64
Elemental Analysis: C, 67.55; H, 8.01; N, 2.72; O, 21.72


Synonym: UK 79300, UK-79300, UK79300, Candoxatril

IUPAC/Chemical Name: 4-[[1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid

InChi Key: ZTWZVMIYIIVABD-RZMWZJFBSA-N

InChi Code: InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21?,23-,24?/m0/s1

SMILES Code: O=C(C1CCC(NC(C2(C[C@@H](COCCOC)C(OC3=CC4=C(CCC4)C=C3)=O)CCCC2)=O)CC1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Singh JS, Lang CC. Angiotensin receptor-neprilysin inhibitors: clinical
potential in heart failure and beyond. Vasc Health Risk Manag. 2015 Jun
1;11:283-95. doi: 10.2147/VHRM.S55630. eCollection 2015. Review. PubMed PMID:
26082640; PubMed Central PMCID: PMC4459540.

2: Vardeny O, Miller R, Solomon SD. Combined neprilysin and renin-angiotensin
system inhibition for the treatment of heart failure. JACC Heart Fail. 2014
Dec;2(6):663-70. doi: 10.1016/j.jchf.2014.09.001. Epub 2014 Oct 8. Review. PubMed
PMID: 25306450.

3: Eizenberg Y, Grossman E, Peleg E, Shabtai Z, Sharabi Y. Neutral endopeptidase
inhibitor versus angiotensin converting enzyme inhibitor in a rat model of the
metabolic syndrome. J Am Soc Hypertens. 2014 Apr;8(4):227-31. doi:
10.1016/j.jash.2014.01.006. Epub 2014 Jan 24. PubMed PMID: 24560177.