Candesartan
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317364

CAS#: 139481-59-7

Description: Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan is marketed as the cyclohexyl 1-hydroxyethyl carbonate (cilexetil) ester, known as candesartan cilexetil. Candesartan cilexetil is metabolised completely by esterases in the intestinal wall during absorption to the active candesartan moieity. The use of a prodrug form increases the bioavailability of candesartan. Despite this, absolute bioavailability is relatively poor at 15% (candesartan cilexetil tablets) to 40% (candesartan cilexetil solution). Its IC50 is 15 µg/kg.


Price and Availability

Size
Price

10mg
USD 60
100mg
USD 90
1g
USD 450
Size
Price

25mg
USD 70
200mg
USD 150
2g
USD 850
Size
Price

50mg
USD 80
500mg
USD 250
5g
Ask price

Candesartan purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317364
Name: Candesartan
CAS#: 139481-59-7
Chemical Formula: C24H20N6O3
Exact Mass: 440.15969
Molecular Weight: 440.45
Elemental Analysis: C, 65.45; H, 4.58; N, 19.08; O, 10.90


Synonym: Candesartan, CV11974, CV-1197, CV 11974, Trade names: Blopress, Atacand, Amias, and Ratacand

IUPAC/Chemical Name: 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid

InChi Key: HTQMVQVXFRQIKW-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)

SMILES Code: O=C(C1=C2N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(OCC)=NC2=CC=C1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wolska E, Kluk A, Zarazińska M, Boniecka M, Sznitowska M. Choice of excipients
for gelly-like pulp prepared ex tempore "on a spoon"- "placebo" and with sartans.
Drug Dev Ind Pharm. 2015 Nov 7:1-10. [Epub ahead of print] PubMed PMID: 26548554.

2: Enatsu N, Miyake H, Chiba K, Fujisawa M. Candesartan Mediated Amelioration of
Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression
Patterns of Nephrin and Podocin. Biomed Res Int. 2015;2015:273784. doi:
10.1155/2015/273784. Epub 2015 Oct 11. PubMed PMID: 26539476; PubMed Central
PMCID: PMC4619786.

3: Quiñones MM, Maldonado L, Velazquez B, Porter JT. Candesartan ameliorates
impaired fear extinction induced by innate immune activation. Brain Behav Immun.
2015 Oct 28. pii: S0889-1591(15)30043-X. doi: 10.1016/j.bbi.2015.10.017. [Epub
ahead of print] PubMed PMID: 26520214.