Benazepril hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317310

CAS#: 86541-74-4 (HCl)

Description: Benazepril Hydrochloride is the hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Benazepril hydrochloride reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.


Price and Availability

Size
Price

100mg
USD 150
1g
USD 650
Size
Price

200mg
USD 250
2g
USD 950
Size
Price

500mg
USD 450
5g
USD 1650

Benazepril hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317310
Name: Benazepril hydrochloride
CAS#: 86541-74-4 (HCl)
Chemical Formula: C24H29ClN2O5
Exact Mass:
Molecular Weight: 460.95
Elemental Analysis: C, 62.54; H, 6.34; Cl, 7.69; N, 6.08; O, 17.35


Related CAS #: 86541-75-5 (free base)   86541-74-4 (HCl)    

Synonym: Benazepril hydrochloride; Benazepril; benazepril hydrochloride; benzazepril; Briem; CGS-14824-A; CGS-14824A; Cibacène; Cibacen; Labopal; Lotensin

IUPAC/Chemical Name: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride

InChi Key: VPSRQEHTHIMDQM-FKLPMGAJSA-N

InChi Code: InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

SMILES Code: O=C(O)CN1C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)CCC3=CC=CC=C31)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic
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18: Peng DF, Tang SY, Hu YJ, Chen J, Peng X, Huang Q. Comparison of valsartan and
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