Bumetanide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317355

CAS#: 28395-03-1

Description: Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.


Price and Availability

Size
Price

10mg
USD 60
100mg
USD 90
1g
USD 350
10g
USD 1650
Size
Price

25mg
USD 65
200mg
USD 120
2g
USD 550
20g
USD 2650
Size
Price

50mg
USD 70
500mg
USD 190
5g
USD 1050
50g
Ask price

Bumetanide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317355
Name: Bumetanide
CAS#: 28395-03-1
Chemical Formula: C17H20N2O5S
Exact Mass: 364.10929
Molecular Weight: 364.4161
Elemental Analysis: C, 56.03; H, 5.53; N, 7.69; O, 21.95; S, 8.80


Synonym: Bumetanide, Trade names: Bumex or Burinex; PF 1593, PF-1593, PF1593

IUPAC/Chemical Name: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid

InChi Key: MAEIEVLCKWDQJH-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)

SMILES Code: O=C(O)C1=CC(S(=O)(N)=O)=C(OC2=CC=CC=C2)C(NCCCC)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Mitsui R, Hashitani H. Mechanisms underlying spontaneous constrictions of
postcapillary venules in the rat stomach. Pflugers Arch. 2015 Nov 4. [Epub ahead
of print] PubMed PMID: 26530829.

2: Krueger D, Michel K, Zeller F, Demir IE, Ceyhan GO, Slotta-Huspenina J,
Schemann M. Neural influences on human intestinal epithelium in vitro. J Physiol.
2015 Nov 2. doi: 10.1113/JP271493. [Epub ahead of print] PubMed PMID: 26527433.

3: Pressler RM, Boylan GB, Marlow N, de Vries LS, Blennow M, Chiron C, Cross JH,
Hallberg B, Hellström-Westas L, Jullien V, Mangum B, Murphy B, Murray D, Pons G,
Rennie J, Toet MC, Zohar S; NEMO consortium (NEonatal seizure treatment with
Medication Off-patent). Bumetanide for neonatal seizures-back from the cotside.
Nat Rev Neurol. 2015 Nov 3. doi: 10.1038/nrneurol.2015.116. [Epub ahead of print]
PubMed PMID: 26526530.