Buclizine HCl
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317354

CAS#: 129-74-8 (HCl)

Description: Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 1650
Size
Price

25mg
USD 150
200mg
USD 650
2g
USD 2450
Size
Price

50mg
USD 250
500mg
USD 950
5g
USD 3450

Buclizine HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 317354
Name: Buclizine HCl
CAS#: 129-74-8 (HCl)
Chemical Formula: C28H35Cl3N2
Exact Mass: 432.23323
Molecular Weight: 505.952
Elemental Analysis: C, 66.47; H, 6.97; Cl, 21.02; N, 5.54


Related CAS #: 129-74-8 (HCl)   82-95-1 (free base).  

Synonym: AH 2526, AH-2526, AH2526; Buclizine; Buclizine dihydrochloride; UCB-4445, Buclina, Longifene, Posdel, Vibazine.

IUPAC/Chemical Name: 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride

InChi Key: SDBHDSZKNVDKNU-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H

SMILES Code: ClC1=CC=C(C(N2CCN(CC3=CC=C(C(C)(C)C)C=C3)CC2)C4=CC=CC=C4)C=C1.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kuminek G, Stulzer HK, Tagliari MP, Oliveira PR, Bernardi LS, Rauber GS,
Cardoso SG. High-performance column liquid chromatographic method for the
simultaneous determination of buclizine, tryptophan, pyridoxine, and
cyanocobalamin in tablets and oral suspension. J AOAC Int. 2011
Nov-Dec;94(6):1785-90. PubMed PMID: 22320085.

2: Babu TA. Buclizine is back again! This time as a pediatric appetite stimulant.
Indian J Pharmacol. 2011 Apr;43(2):219. doi: 10.4103/0253-7613.77383. PubMed
PMID: 21572667; PubMed Central PMCID: PMC3081471.

3: Mostafa GA, Al-Badr AA. Buclizine. Profiles Drug Subst Excip Relat Methodol.
2011;36:1-33. doi: 10.1016/B978-0-12-387667-6.00001-4. Epub 2011 Jun 23. PubMed
PMID: 22469258.