Benzquinamide hydrochloride
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317315

CAS#: 113-69-9

Description: Benzquinamide hydrochloride is a benzquinamide is an antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.


Price and Availability

Size
Price

5mg
USD 280
Size
Price

Size
Price

Benzquinamide hydrochloride purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 317315
Name: Benzquinamide hydrochloride
CAS#: 113-69-9
Chemical Formula: C22H33ClN2O5
Exact Mass:
Molecular Weight: 440.96
Elemental Analysis: C, 59.92; H, 7.54; Cl, 8.04; N, 6.35; O, 18.14


Synonym: Benzquinamide hydrochloride; P-2647 hydrochloride; Benzquinamida;

IUPAC/Chemical Name: [3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] acetate

InChi Key: JSZILQVIPPROJI-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H32N2O5/c1-6-23(7-2)22(26)17-13-24-9-8-15-10-20(27-4)21(28-5)11-16(15)18(24)12-19(17)29-14(3)25/h10-11,17-19H,6-9,12-13H2,1-5H3

SMILES Code: [H]Cl.CC(OC1C(C(N(CC)CC)=O)CN2CCC3=CC(OC)=C(OC)C=C3C2C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gregori-Puigjané E, Setola V, Hert J, Crews BA, Irwin JJ, Lounkine E, Marnett
L, Roth BL, Shoichet BK. Identifying mechanism-of-action targets for drugs and
probes. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11178-83. doi:
10.1073/pnas.1204524109. Epub 2012 Jun 18. PubMed PMID: 22711801; PubMed Central
PMCID: PMC3396511.

2: Mazzanti R, Croop JM, Gatmaitan Z, Budding M, Steiglitz K, Arceci R, Arias IM.
Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates
anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res.
1992;4(8-9):359-65. PubMed PMID: 1362504.

3: Maurer H, Pfleger K. Identification and differentiation of alkylamine
antihistamines and their metabolites in urine by computerized gas
chromatography-mass spectrometry. J Chromatogr. 1988 Aug 19;430(1):31-41. PubMed
PMID: 2905706.

4: Laszlo J. Nausea and vomiting as major complications of cancer chemotherapy.
Drugs. 1983 Feb;25 Suppl 1:1-7. PubMed PMID: 6840017.

5: Nietsch P. [Dose-response relationship of intravenous administration of
benzquinamide hydrochloride for suppression of cytostatic-induced emesis].
Arzneimittelforschung. 1983;33(12):1694-5. German. PubMed PMID: 6689400.

6: Niemegeers CJ. Antiemetic specificity of dopamine antagonists.
Psychopharmacology (Berl). 1982;78(3):210-3. PubMed PMID: 6130555.

7: Neidhart JA, Gagen M, Young D, Wilson HE. Specific antiemetics for specific
cancer chemotherapeutic agents: haloperidol versus benzquinamide. Cancer. 1981
Mar 15;47(6):1439-43. PubMed PMID: 7013968.

8: Coruzzi G, Scarpignato C, Zappia L, Bertaccini G. [Effect of benzquinamide on
gastrointestinal motility]. Farmaco Prat. 1980 Sep;35(9):466-72. Italian. PubMed
PMID: 6893823.

9: Smith DJ, Rushin JM, Urquilla PR, Rhee CW, Yoon HJ, Simpson FA, Srichomkuan T,
Lee HS, Knapp RB. Cardiovascular effects of benzquinamide. Anesth Analg. 1979
May-Jun;58(3):189-94. PubMed PMID: 582237.

10: Hobbs DC, Connolly AG. Pharmacokinetics of benzquinamide in man. J
Pharmacokinet Biopharm. 1978 Dec;6(6):477-85. PubMed PMID: 581593.

11: Amin MM, Ban TA, Lehmann HE. A standard-controlled clinical study with
benzquinamide in the treatment of chronic schizophrenic patients. Psychopharmacol
Bull. 1977 Jul;13(3):20-1. PubMed PMID: 329325.

12: Chapin JW, Wingard DW. Physostigmine reversal of benzquinamide-induced
delirium. Anesthesiology. 1977 May;46(5):364-5. PubMed PMID: 576777.

13: Moertel CG, Schutt AJ, Hahn RG, O'Fallon JR. Oral benzquinamide in the
treatment of nausea and vomiting. Clin Pharmacol Ther. 1975 Nov;18(5 Pt 1):554-7.
PubMed PMID: 1102233.

14: Rose TE, Averbuch SD. Letter: Acute dystonic reaction due to benzquinamide.
Ann Intern Med. 1975 Aug;83(2):231-2. PubMed PMID: 1173745.

15: Leander JD. Rate-dependent Effects of drugs. II. effects of some major
tranquilizers on multiple fixed-ratio, fixed-interval schedule performance. J
Pharmacol Exp Ther. 1975 May;193(2):689-700. PubMed PMID: 238028.

16: Kingston RS, Heurich AE, Thomas JS, Steen SN. Cardiovascular effects of
benzquinamide in man. Acta Anaesthesiol Scand. 1975;19(3):187-92. PubMed PMID:
241192.

17: Mull TD, Smith TC. Comparison of the ventilatory effects of two antiemetics,
benzquinamide and prochlorperazine. Anesthesiology. 1974 Jun;40(6):581-7. PubMed
PMID: 4406574.

18: Kleibel F, Immich H. [Antiemetic effect of benzquinamide in generalized
radiation reaction]. Ther Ggw. 1973 May;112(5):820 passim. German. PubMed PMID:
4740156.

19: Steen SN, Yates M. The effects of benzquinamide and prochlorperazine,
separately and combined, on the human respiratory center. Anesthesiology. 1972
May;36(5):519-20. PubMed PMID: 5067296.

20: Lutz H, Immich H. Antiemetic effect of benzquinamide in postoperative
vomiting. Curr Ther Res Clin Exp. 1972 Apr;14(4):178-84. PubMed PMID: 4623597.