Benzphetamine HCl
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MedKoo CAT#: 317314

CAS#: 5411-22-3

Description: Benzphetamine Hydrochloride is the hydrochloride salt form of benzphetamine, a sympathomimetic amine related to the synthetic agent amphetamine with central nervous system stimulating and anorexic properties. Benzphetamine stimulates the release of certain catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. The increase in synaptic concentrations of these catecholamines causes behavioral changes including euphoria, an increase in mental alertness and excitement, and suppresses appetite.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
Size
Price

25mg
USD 150
200mg
USD 850
Size
Price

50mg
USD 250

Benzphetamine HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317314
Name: Benzphetamine HCl
CAS#: 5411-22-3
Chemical Formula: C17H22ClN
Exact Mass:
Molecular Weight: 275.82
Elemental Analysis: C, 74.03; H, 8.04; Cl, 12.85; N, 5.08


Synonym: Benzphetamine HCl; Inapetyl; Didrex; D-Benzphetamine hydrochloride.

IUPAC/Chemical Name: N-benzyl-N-methyl-1-phenylpropan-2-amine;hydrochloride

InChi Key: ANFSNXAXVLRZCG-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21N.ClH/c1-15(13-16-9-5-3-6-10-16)18(2)14-17-11-7-4-8-12-17;/h3-12,15H,13-14H2,1-2H3;1H

SMILES Code: CC(N(CC1=CC=CC=C1)C)CC2=CC=CC=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Konstantinos L, Karavis M, Mastorakos G, Valsamakis G. New molecular targets
for the Pharmacotherapy of Obesity. 2015 Apr 8. In: De Groot LJ, Beck-Peccoz P,
Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar
R, Singer F, Vinik A, Weickert MO, editors. Endotext [Internet]. South Dartmouth
(MA): MDText.com, Inc.; 2000-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK279143/
PubMed PMID: 25905366.

2: Joo JK, Lee KS. Pharmacotherapy for obesity. J Menopausal Med. 2014
Dec;20(3):90-6. doi: 10.6118/jmm.2014.20.3.90. Epub 2014 Dec 24. Review. PubMed
PMID: 25580419; PubMed Central PMCID: PMC4286660.

3: Celik G, Semiz A, Karakurt S, Gencler-Ozkan AM, Arslan S, Adali O, Sen A.
Inhibitory action of Epilobium hirsutum extract and its constituent ellagic acid
on drug-metabolizing enzymes. Eur J Drug Metab Pharmacokinet. 2014 Nov 26. [Epub
ahead of print] PubMed PMID: 25425117.

4: King LA. New phenethylamines in Europe. Drug Test Anal. 2014
Jul-Aug;6(7-8):808-18. doi: 10.1002/dta.1570. Epub 2013 Nov 5. Review. PubMed
PMID: 24574327.

5: Hampp C, Kang EM, Borders-Hemphill V. Use of prescription antiobesity drugs in
the United States. Pharmacotherapy. 2013 Dec;33(12):1299-307. doi:
10.1002/phar.1342. Epub 2013 Sep 9. PubMed PMID: 24019195.

6: Ménard C, Tse YC, Cavanagh C, Chabot JG, Herzog H, Schwarzer C, Wong TP,
Quirion R. Knockdown of prodynorphin gene prevents cognitive decline, reduces
anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in
aging. J Neurosci. 2013 Jul 31;33(31):12792-804. doi:
10.1523/JNEUROSCI.0290-13.2013. PubMed PMID: 23904614.

7: Kenaan C, Shea EV, Lin HL, Zhang H, Pratt-Hyatt MJ, Hollenberg PF.
Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome
P450 reductase and substrate metabolism. Drug Metab Dispos. 2013
Jan;41(1):101-10. doi: 10.1124/dmd.112.046094. Epub 2012 Oct 5. PubMed PMID:
23043184; PubMed Central PMCID: PMC3533429.

8: Kwon W, Kim JY, Suh S, In MK. Rapid and simple determination of psychotropic
phenylalkylamine derivatives in urine by direct injection liquid
chromatography-electrospray ionization-tandem mass spectrometry. Biomed
Chromatogr. 2013 Jan;27(1):88-95. doi: 10.1002/bmc.2752. Epub 2012 Apr 25. PubMed
PMID: 22532383.

9: Carrara S, Cavallini A, Erokhin V, De Micheli G. Multi-panel drugs detection
in human serum for personalized therapy. Biosens Bioelectron. 2011 May
15;26(9):3914-9. doi: 10.1016/j.bios.2011.03.009. Epub 2011 Mar 17. PubMed PMID:
21497079.

10: Myasoedova KN, Timofeev KN. Conformational changes near the cytochrome P450
active site upon binding of two different ligands. Biochemistry (Mosc). 2010
Jul;75(7):899-904. PubMed PMID: 20673214.

11: Perera R, Sono M, Kinloch R, Zhang H, Tarasev M, Im SC, Waskell L, Dawson JH.
Stabilization and spectroscopic characterization of the dioxygen complex of
wild-type cytochrome P4502B4 (CYP2B4) and its distal side E301Q, T302A and
proximal side F429H mutants at subzero temperatures. Biochim Biophys Acta. 2011
Jan;1814(1):69-75. doi: 10.1016/j.bbapap.2010.07.012. Epub 2010 Jul 13. PubMed
PMID: 20637316.

12: Virkel G, Carletti M, Cantiello M, Della Donna L, Gardini G, Girolami F,
Nebbia C. Characterization of xenobiotic metabolizing enzymes in bovine small
intestinal mucosa. J Vet Pharmacol Ther. 2010 Jun 1;33(3):295-303. doi:
10.1111/j.1365-2885.2009.01137.x. PubMed PMID: 20557447.

13: Zhang H, Lin HL, Walker VJ, Hamdane D, Hollenberg PF.
tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome
P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance. Mol
Pharmacol. 2009 Nov;76(5):1011-8. doi: 10.1124/mol.109.059808. Epub 2009 Aug 31.
PubMed PMID: 19720728; PubMed Central PMCID: PMC2774989.

14: Zhang H, Kenaan C, Hamdane D, Hoa GH, Hollenberg PF. Effect of conformational
dynamics on substrate recognition and specificity as probed by the introduction
of a de novo disulfide bond into cytochrome P450 2B1. J Biol Chem. 2009 Sep
18;284(38):25678-86. doi: 10.1074/jbc.M109.032748. Epub 2009 Jul 15. PubMed PMID:
19605359; PubMed Central PMCID: PMC2757969.

15: Li W, Tang Y, Hoshino T, Neya S. Molecular modeling of human cytochrome P450
2W1 and its interactions with substrates. J Mol Graph Model. 2009
Sep;28(2):170-6. doi: 10.1016/j.jmgm.2009.06.002. Epub 2009 Jun 21. PubMed PMID:
19596602.

16: Vilches-Herrera M, Miranda-Sepúlveda J, Rebolledo-Fuentes M, Fierro A, Lühr
S, Iturriaga-Vasquez P, Cassels BK, Reyes-Parada M. Naphthylisopropylamine and
N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem.
2009 Mar 15;17(6):2452-60. doi: 10.1016/j.bmc.2009.01.074. Epub 2009 Feb 8.
PubMed PMID: 19243954.

17: Sheng X, Zhang H, Im SC, Horner JH, Waskell L, Hollenberg PF, Newcomb M.
Kinetics of oxidation of benzphetamine by compounds I of cytochrome P450 2B4 and
its mutants. J Am Chem Soc. 2009 Mar 4;131(8):2971-6. doi: 10.1021/ja808982g.
PubMed PMID: 19209859; PubMed Central PMCID: PMC2765530.

18: Gurevich-Panigrahi T, Panigrahi S, Wiechec E, Los M. Obesity: pathophysiology
and clinical management. Curr Med Chem. 2009;16(4):506-21. Review. PubMed PMID:
19199918.

19: Hamdane D, Xia C, Im SC, Zhang H, Kim JJ, Waskell L. Structure and function
of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of
reducing cytochrome P450. J Biol Chem. 2009 Apr 24;284(17):11374-84. doi:
10.1074/jbc.M807868200. Epub 2009 Jan 26. PubMed PMID: 19171935; PubMed Central
PMCID: PMC2670143.

20: Shebley M, Kent UM, Ballou DP, Hollenberg PF. Mechanistic analysis of the
inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate
binding, electron transfer, and uncoupling. Drug Metab Dispos. 2009
Apr;37(4):745-52. doi: 10.1124/dmd.108.024661. Epub 2009 Jan 14. PubMed PMID:
19144770; PubMed Central PMCID: PMC2680542.