Acyclovir
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317158

CAS#: 59277-89-3

Description: Acyclovir is an antiviral agent with activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication. It induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).


Price and Availability

Size
Price

100mg
USD 50
1g
USD 150
10g
USD 450
100g
Ask price
Size
Price

200mg
USD 70
2g
USD 190
20g
USD 650
1kg
Ask price
Size
Price

500mg
USD 90
5g
USD 250
50g
USD 950

Acyclovir, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 317158
Name: Acyclovir
CAS#: 59277-89-3
Chemical Formula: C8H11N5O3
Exact Mass: 225.08619
Molecular Weight: 225.21
Elemental Analysis: C, 42.67; H, 4.92; N, 31.10; O, 21.31


Synonym: Acyclovir; Acycloguanosine; Aciclovir; Zovirax; Vipral.

IUPAC/Chemical Name: 2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one

InChi Key: MKUXAQIIEYXACX-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

SMILES Code: C1=NC2=C(N1COCCO)NC(=NC2=O)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Srinivas NR. The Interesting Case of Acyclovir Delivered Using Chitosan in Humans: Is it a Drug Issue or Formulation Issue? Pharm Res. 2015 Oct 16. [Epub ahead of print] PubMed PMID: 26474764.

2: Sahu PK, Umme T, Yu J, Nayak A, Kim G, Noh M, Lee JY, Kim DD, Jeong LS. Seleno-acyclovir and -ganciclovir: A Discovery of a New Template for Antiviral Agents. J Med Chem. 2015 Oct 13. [Epub ahead of print] PubMed PMID: 26460883.

3: Kazi M, Al-Amri KA, Alanazi FK. The role of lipid-based drug delivery systems for enhancing solubility of highly selective antiviral agent acyclovir. Pharm Dev Technol. 2015 Oct 13:1-10. [Epub ahead of print] PubMed PMID: 26458371.

4: Sánchez-Sánchez MP, Martín-Illana A, Ruiz-Caro R, Bermejo P, Abad MJ, Carro R, Bedoya LM, Tamayo A, Rubio J, Fernández-Ferreiro A, Otero-Espinar F, Veiga MD. Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation. Mar Drugs. 2015 Sep 18;13(9):5976-92. doi: 10.3390/md13095976. PubMed PMID: 26393621; PubMed Central PMCID: PMC4584363.

5: Vaithianathan S, Haidar SH, Zhang X, Jiang W, Avon C, Dowling TC, Shao C, Kane M, Hoag SW, Flasar MH, Ting TY, Polli JE. Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir. J Pharm Sci. 2015 Sep 16. doi: 10.1002/jps.24643. [Epub ahead of print] PubMed PMID: 26375604.

6: Lee HJ, Kim JM, Kim GW, Mun JH, Song M, Kim HS, Kim BS, Kim MB, Ko HC. Fixed drug eruption due to acyclovir, valacyclovir and famciclovir. J Eur Acad Dermatol Venereol. 2015 Sep 15. doi: 10.1111/jdv.13261. [Epub ahead of print] PubMed PMID: 26369523.

7: An J, Li G, An T, Nie X. Indirect photochemical transformations of acyclovir and penciclovir in aquatic environments increase ecological risk. Environ Toxicol Chem. 2015 Sep 10. doi: 10.1002/etc.3238. [Epub ahead of print] PubMed PMID: 26356329.

8: Al-Ghabeish M, Xu X, Krishnaiah YS, Rahman Z, Yang Y, Khan MA. Influence of drug loading and type of ointment base on the in vitro performance of acyclovir ophthalmic ointment. Int J Pharm. 2015 Sep 4;495(2):783-791. doi: 10.1016/j.ijpharm.2015.08.096. [Epub ahead of print] PubMed PMID: 26343911.

9: Kharia AA, Singhai AK. Development and optimisation of mucoadhesive nanoparticles of acyclovir using design of experiments approach. J Microencapsul. 2015 Sep;32(6):521-32. doi: 10.3109/02652048.2015.1010457. Epub 2015 Aug 18. PubMed PMID: 26333938.

10: Zhou C, Chen J, Xie Q, Wei X, Zhang YN, Fu Z. Photolysis of three antiviral drugs acyclovir, zidovudine and lamivudine in surface freshwater and seawater. Chemosphere. 2015 Nov;138:792-7. doi: 10.1016/j.chemosphere.2015.08.033. Epub 2015 Aug 18. PubMed PMID: 26295538.