JH-II-127
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522462

CAS#: 1700693-08-8

Description: JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg. Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target.


Price and Availability

Size
Price

100mg
USD 850
1g
USD 2950
Size
Price

200mg
USD 1250
2g
USD 4650
Size
Price

500mg
USD 1950
5g
Ask price

JH-II=127, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522462
Name: JH-II-127
CAS#: 1700693-08-8
Chemical Formula: C19H21ClN6O3
Exact Mass: 416.13637
Molecular Weight: 416.87
Elemental Analysis: C, 54.74; H, 5.08; Cl, 8.50; N, 20.16; O, 11.51


Synonym: JH-II-127; JH-II 127; JH-II127.

IUPAC/Chemical Name: (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone

InChi Key: HUEKBQXFNHWTQQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)

SMILES Code: ClC1=CNC2=C1C(NC)=NC(NC3=C(OC)C=C(C(N4CCOCC4)=O)C=C3)=N2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS. Discovery of a
Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant
LRRK2 Inhibitor. ACS Med Chem Lett. 2015 Apr 7;6(5):584-9. doi:
10.1021/acsmedchemlett.5b00064. eCollection 2015 May 14. PubMed PMID: 26005538;
PubMed Central PMCID: PMC4434483.