Y-320
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522442

CAS#: 288250-47-5

Description: Y-320 is an orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.


Price and Availability

Size
Price

100mg
USD 1350
1g
USD 3950
Size
Price

200mg
USD 2150
2g
USD 5250
Size
Price

500mg
USD 2950
5g
USD 8650

Y-320, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522442
Name: Y-320
CAS#: 288250-47-5
Chemical Formula: C27H29ClN6O2
Exact Mass: 504.20405
Molecular Weight: 505.01
Elemental Analysis: C, 64.21; H, 5.79; Cl, 7.02; N, 16.64; O, 6.34


Synonym: Y-320; Y320; Y 320

IUPAC/Chemical Name: 1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide

InChi Key: BWZNJVZTAWBIFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35)

SMILES Code: O=C(C1=C(C)N(C2=CC=C(Cl)C=C2)N=C1)NC3=CC=C(N4CCC(N5CCOCC5)CC4)C(C#N)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sun D, Flock T, Deupi X, Maeda S, Matkovic M, Mendieta S, Mayer D, Dawson RJ, Schertler GF, Babu MM, Veprintsev DB. Probing Gαi1 protein activation at single-amino acid resolution. Nat Struct Mol Biol. 2015 Sep;22(9):686-94. doi: 10.1038/nsmb.3070. Epub 2015 Aug 10. PubMed PMID: 26258638.

2: Lin X, Zhong S, Ye X, Liao Y, Yao F, Yang X, Sun B, Zhang J, Li Q, Gao Y, Wang Y, Liu J, Han B, Chin YE, Zhou BP, Deng J. EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer. Mol Cancer. 2014 Oct 14;13:233. doi: 10.1186/1476-4598-13-233. PubMed PMID: 25311788; PubMed Central PMCID: PMC4200229.

3: Klyuyeva A, Tuganova A, Popov KM. Allosteric coupling in pyruvate dehydrogenase kinase 2. Biochemistry. 2008 Aug 12;47(32):8358-66. doi: 10.1021/bi800631h. Epub 2008 Jul 16. PubMed PMID: 18627174; PubMed Central PMCID: PMC2568900.

4: Kane BE, McCurdy CR, Ferguson DM. Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. J Med Chem. 2008 Mar 27;51(6):1824-30. doi: 10.1021/jm701040v. Epub 2008 Feb 23. PubMed PMID: 18293909.

5: Noviello CM, Benichou S, Guatelli JC. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol. 2008 Feb;82(3):1249-58. Epub 2007 Dec 5. PubMed PMID: 18057255; PubMed Central PMCID: PMC2224416.

6: Kane BE, Nieto MJ, McCurdy CR, Ferguson DM. A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist. FEBS J. 2006 May;273(9):1966-74. PubMed PMID: 16640560.