UPF-1069
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407176

CAS#: 1048371-03-4

Description: UPF-1069 is a selective and potent PARP2 inhibitor. UPF-1069 induces apoptosis. UPF-1069 shows neuroprotective and anti-ischemic effects in vivo.


Chemical Structure

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UPF-1069
CAS# 1048371-03-4

Theoretical Analysis

MedKoo Cat#: 407176
Name: UPF-1069
CAS#: 1048371-03-4
Chemical Formula: C17H13NO3
Exact Mass: 279.09
Molecular Weight: 279.290
Elemental Analysis: C, 73.11; H, 4.69; N, 5.02; O, 17.19

Price and Availability

Size Price Availability Quantity
5g USD -1
10mg USD 110
25mg USD 150
50mg USD 250
100mg USD 450
200mg USD 750
500mg USD 1250
1g USD 1950
2g USD 2950
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Synonym: UPF-1069, UPF1069, UPF 1069

IUPAC/Chemical Name: 5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one

InChi Key: JJWMRRNGWSITSQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20)

SMILES Code: O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 279.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gerace E, Scartabelli T, Formentini L, Landucci E, Moroni F, Chiarugi A, Pellegrini-Giampietro DE. Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance. Eur J Neurosci. 2012 Jul;36(1):1993-2005. doi: 10.1111/j.1460-9568.2012.08116.x. Epub 2012 May 28. PubMed PMID: 22639866.

2: Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5. PubMed PMID: 19422384; PubMed Central PMCID: PMC2721269.