C646
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407171

CAS#: 328968-36-1

Description: C646 is a potent histone acetyltransferase p300 inhibitor. C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. C646 radiosensitizes lung cancer cells by enhancing mitotic catastrophe. C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Note: this molecule exists as a mixture of cis- and trans- isomers.


Price and Availability

Size
Price

2mg
USD 70
2g
USD 4950
Size
Price

5mg
USD 120
5g
USD 6850
Size
Price

1g
USD 2950
10g
Ask price

C646, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407171
Name: C646
CAS#: 328968-36-1
Chemical Formula: C24H19N3O6
Exact Mass: 445.12739
Molecular Weight: 445.43
Elemental Analysis: C, 64.72; H, 4.30; N, 9.43; O, 21.55


Synonym: C646; C-646; C 646.

IUPAC/Chemical Name: (E)-4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

InChi Key: HEKJYZZSCQBJGB-XDHOZWIPSA-N

InChi Code: InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+

SMILES Code: O=C(O)C1=CC=C(N2N=C(C)/C(C2=O)=C\C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)C=C1


Technical Data

Appearance:
Orange to red solid powder

Purity:
>98% (Note: this molecule exists as a mixture of cis- and trans- isomers)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yang Y, Liu K, Liang Y, Chen Y, Chen Y, Gong Y. Histone acetyltransferase
inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal
mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Int J
Clin Exp Pathol. 2015 Mar 1;8(3):2746-54. eCollection 2015. PubMed PMID:
26045780; PubMed Central PMCID: PMC4440089.

2: Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N,
Nakano T, Kohno T. C646, a selective small molecule inhibitor of histone
acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic
catastrophe. Radiother Oncol. 2014 May;111(2):222-7. doi:
10.1016/j.radonc.2014.03.015. Epub 2014 Apr 17. PubMed PMID: 24746574.

3: Gao XN, Lin J, Ning QY, Gao L, Yao YS, Zhou JH, Li YH, Wang LL, Yu L. A
histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and
apoptosis selectively in AML1-ETO-positive AML cells. PLoS One. 2013;8(2):e55481.
doi: 10.1371/journal.pone.0055481. Epub 2013 Feb 4. PubMed PMID: 23390536; PubMed
Central PMCID: PMC3563640.