ZPL-3893787

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522410

CAS#: 943057-12-3

Description: ZPL-3893787, also known as PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. ZPL-3893787 shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies.


Price and Availability

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Price

1g
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Size
Price

2g
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Size
Price

5g
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ZPL-3893787 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522410
Name: ZPL-3893787
CAS#: 943057-12-3
Chemical Formula: C13H22N6
Exact Mass: 262.19059
Molecular Weight: 262.36
Elemental Analysis: C, 59.51; H, 8.45; N, 32.03


Synonym: ZPL-3893787; ZPL3893787; ZPL 3893787; ZPL-389; ZPL 389; ZPL389; PF-03893787; PF03893787; PF 03893787; PF-3893787; PF3893787; PF 3893787.

IUPAC/Chemical Name: (R)-N4-(cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine

InChi Key: ISBHYKVAFKTATD-SNVBAGLBSA-N

InChi Code: InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1

SMILES Code: NC1=NC(N2CC[C@@H](NC)C2)=CC(NCC3CC3)=N1


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Andaloussi M, Lim HD, van der Meer T, Sijm M, Poulie CB, de Esch IJ, Leurs R,
Smits RA. A novel series of histamine H4 receptor antagonists based on the
pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence
time with PF-3893787. Bioorg Med Chem Lett. 2013 May 1;23(9):2663-70. doi:
10.1016/j.bmcl.2013.02.091. Epub 2013 Mar 1. PubMed PMID: 23558237.

2: Salcedo C, Pontes C, Merlos M. Is the H4 receptor a new drug target for
allergies and asthma? Front Biosci (Elite Ed). 2013 Jan 1;5:178-87. Review.
PubMed PMID: 23276980.

3: Mowbray CE, Bell AS, Clarke NP, Collins M, Jones RM, Lane CA, Liu WL, Newman
SD, Paradowski M, Schenck EJ, Selby MD, Swain NA, Williams DH. Challenges of drug
discovery in novel target space. The discovery and evaluation of PF-3893787: a
novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov
1;21(21):6596-602. doi: 10.1016/j.bmcl.2011.07.125. Epub 2011 Aug 9. PubMed PMID:
21920751.