QNZ46
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522398

CAS#: 1237744-13-6

Description: QNZ46 is a NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 1950
Size
Price

25mg
USD 250
200mg
USD 950
2g
USD 2950
Size
Price

50mg
USD 450
500mg
USD 1450
5g
Ask price

QNZ46, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522398
Name: QNZ46
CAS#: 1237744-13-6
Chemical Formula: C24H17N3O6
Exact Mass: 443.11174
Molecular Weight: 443.42
Elemental Analysis: C, 65.01; H, 3.86; N, 9.48; O, 21.65


Synonym: QNZ46; QNZ-46; QNZ 46.

IUPAC/Chemical Name: (E)-4-(6-methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid

SMILES Code: O=C(O)C1=CC=C(N2C(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NC4=C(C=C(OC)C=C4)C2=O)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel
site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J
Neurosci. 2011 Mar 9;31(10):3650-61. doi: 10.1523/JNEUROSCI.5565-10.2011. PubMed
PMID: 21389220; PubMed Central PMCID: PMC3063124.