SW033291
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522396

CAS#: 459147-39-8

Description: SW033291 is a potent and selective 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme inhibitor. 15-PGDH is a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. SW033291 also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. Thus, 15-PGDH inhibition may be a valuable therapeutic strategy for tissue regeneration in diverse clinical contexts.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2650
10g
USD 8950
Size
Price

25mg
USD 250
200mg
USD 950
2g
USD 3850
20g
Ask price
Size
Price

50mg
USD 450
500mg
USD 1650
5g
USD 6950

SW033291, purity > 98%, is in stock . Price updated on 9/26/2016. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522396
Name: SW033291
CAS#: 459147-39-8
Chemical Formula: C21H20N2OS3
Exact Mass: 412.07378
Molecular Weight: 412.58
Elemental Analysis: C, 61.13; H, 4.89; N, 6.79; O, 3.88; S, 23.31


Synonym: SW033291; SW 033291; SW 033291.

IUPAC/Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine

SMILES Code: NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21


Technical Data

Appearance:
Yellow solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE,
Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L,
Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C,
Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK,
Markowitz SD. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading
enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun
12;348(6240):aaa2340. doi: 10.1126/science.aaa2340. PubMed PMID: 26068857; PubMed
Central PMCID: PMC4481126.