HA130

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522395

CAS#: 1229652-21-4

Description: HA130 is a potent and selective autotaxin (ATX) inhibitor (IC50 = 28 nM). HA130 slows T cell migration across lymph node HEVs in vivo. Ex vivo, HA130 blunts the TEM-promoting activity of ATX, paralleling its in vivo effects.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2950
Size
Price

25mg
USD 250
200mg
USD 1350
2g
USD 3950
Size
Price

50mg
USD 450
500mg
USD 1950
5g
Ask price

HA130, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522395
Name: HA130
CAS#: 1229652-21-4
Chemical Formula: C24H19BFNO5S
Exact Mass: 463.1061
Molecular Weight: 463.29
Elemental Analysis: C, 62.22; H, 4.13; B, 2.33; F, 4.10; N, 3.02; O, 17.27; S, 6.92


Synonym: HA130; HA-130; HA 130.

IUPAC/Chemical Name: (Z)-(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N

InChi Code: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-

SMILES Code: OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS.
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer
cells. Cell Signal. 2013 Nov;25(11):2147-54. doi: 10.1016/j.cellsig.2013.07.001.
Epub 2013 Jul 6. PubMed PMID: 23838008.

2: Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ.
Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right
asymmetry in zebrafish. Development. 2012 Dec 1;139(23):4439-48. doi:
10.1242/dev.081745. Epub 2012 Oct 24. PubMed PMID: 23095890.

3: Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic
acid stimulates polarization, motility, and transendothelial migration of naive T
cells. J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub
2012 Sep 7. PubMed PMID: 22962684; PubMed Central PMCID: PMC3509168.